(S)-(+)-Epichlorohydrin
(S)-(+)-Epichlorohydrin (CAS: 67843-74-7; C3H5ClO; MW: 92.52) is a chiral epoxide and a valuable building block for enantioselective syntheses. It is specifically utilised in the creation of complex organic molecules, including biologically relevant compounds. Its defined stereochemistry makes it indispensable for synthesising chiral intermediates and targets, contributing to advancements in pharmaceutical and chemical research.
- IUPAC
- (S)-(+)-2-(Chloromethyl)oxirane
- Synonyms
- (S)-(+)-2-(Chloromethyl)oxirane
Chiral Building Block in Asymmetric Synthesis
Serves as a crucial chiral synthon in the enantioselective synthesis of complex organic molecules. It is instrumental in constructing chiral centres with high stereochemical control, vital for pharmaceutical intermediates.
Synthesis of Hydroxyisoxazolidines
Employed in the synthesis of enantiomerically pure hydroxyisoxazolidines. These compounds are of interest in medicinal chemistry for their potential biological activities.
Precursor to Natural Products
Utilised as a key intermediate in the total synthesis of natural products, such as (+)-cis-sylvaticin, a compound investigated for potential antitumor properties.
| Molecular weight | 92.52 |
|---|---|
| Empirical formula | C3H5ClO |
| Assay | 98% |
| Boiling point | 92-93 °C/360 mmHg(lit.) |
| Density | 1.183 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.438(lit.) |
| Optical activity | [α]20/D +35°, c = 1 in methanol |
| Optical purity | ee: 97% (GLC) |
| Vapour pressure | 12.5 mmHg (20 °C) |
| Vapour density | 3.2 (vs air) |
| Autoignition temp | 1421 °F |
| Application | Chiral building block in the enantioselective syntheses of hydroxyisoxazolidines1 and (+)-cis-sylvaticin, a potential antitumor agent.2 |
Hazard statements
- H226Flammable liquid and vapour
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H314Causes severe skin burns and eye damage
- H317May cause an allergic skin reaction
- H331Toxic if inhaled
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 32 °C / 89.6 °F |
| Transport (UN / ADR) | UN 2023 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-10-23/24/25-34-43 |
| Safety statements (S) | 53-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(+)-Epichlorohydrin used for?
+
(S)-(+)-Epichlorohydrin is used as a chiral building block in enantioselective syntheses, particularly for compounds like hydroxyisoxazolidines and natural products such as (+)-cis-sylvaticin.
What is the CAS number and formula for (S)-(+)-Epichlorohydrin?
+
The CAS number is 67843-74-7 and the empirical formula is C3H5ClO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (S)-(+)-Epichlorohydrin with an assay of 98%. This is a technical grade material and TSS does not represent it as USP, BP, or EP grade.
How should (S)-(+)-Epichlorohydrin be handled?
+
(S)-(+)-Epichlorohydrin is a Danger substance (GHS02, GHS05, GHS06, GHS08) and is flammable (H226). It is toxic if swallowed, in contact with skin, and if inhaled (H301, H311, H331), causes severe skin burns and eye damage (H314), and may cause an allergic skin reaction (H317) and cancer (H350). Handle with appropriate personal protective equipment, including gloves, goggles, and respiratory protection, in a well-ventilated area.
Is (S)-(+)-Epichlorohydrin a controlled substance?
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The provided data does not indicate that (S)-(+)-Epichlorohydrin is a controlled substance.
How is (S)-(+)-Epichlorohydrin shipped or exported?
+
(S)-(+)-Epichlorohydrin is classified as UN 2023, Hazard Class 6.1, Packing Group II, for transport. TSS adheres to all relevant shipping and export regulations.
How can I request a sample or quote for (S)-(+)-Epichlorohydrin?
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Please contact the Tech Serve Solutions sales team directly to request a sample or a quotation for (S)-(+)-Epichlorohydrin.
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