(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone
(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone (CAS: 32780-06-6, C5H8O3) is a chiral building block and versatile synthon. With a molecular weight of 116.12 g/mol, it is primarily utilised in asymmetric synthesis for creating complex natural and unnatural products. Notably, it serves as a key intermediate in the synthesis of mevinic acids, which are known for their cholesterol-lowering properties.
- IUPAC
- (S)-γ-Hydroxymethyl-γ-butyrolactone,(S)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone,(S)-5-Hydroxymethyl-2-oxotetrahydrofuran
- Synonyms
- (S)-γ-Hydroxymethyl-γ-butyrolactone(S)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone(S)-5-Hydroxymethyl-2-oxotetrahydrofuran
Chiral Synthon for Natural Product Synthesis
This compound is a valuable chiral building block used in the stereoselective synthesis of both naturally occurring and synthetic molecules, enabling precise construction of complex architectures.
Intermediate for Mevinic Acid Synthesis
It functions as a crucial synthon in the preparation of mevinic acids, a class of compounds recognised for their efficacy in lowering LDL cholesterol levels.
Asymmetric Synthesis
Leveraged in various asymmetric synthetic routes, this furanone derivative facilitates the introduction of chirality and the creation of enantiomerically pure target compounds.
| Molecular weight | 116.12 |
|---|---|
| Empirical formula | C5H8O3 |
| Assay | 95% |
| Boiling point | 110-115 °C/0.2 mmHg(lit.) |
| Density | 1.237 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.471(lit.) |
| Optical activity | [α]20/D +56°, c = 3 in chloroform |
| Optical purity | ee: 98% (GLC) |
| Storage temperature | 2-8°C |
| Application | Versatile chiral synthon used in the synthesis of natural and unnatural products.1,2,3 Used as a chiral synthon for mevinic acids which are LDL cholesterol lowering agents.2,4 |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone used for?
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(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone is used as a versatile chiral synthon in the synthesis of natural and unnatural products, including mevinic acids for cholesterol-lowering agents.
What are the CAS number and formula for this compound?
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The CAS number is 32780-06-6 and the empirical formula is C5H8O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of 95%. It is not represented as USP, BP, or EP grade.
How should (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone be handled?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a respirator, in a well-ventilated area. Refer to the safety data sheet for comprehensive handling instructions and hazard information. Its flash point is 113 °C.
Is this compound suitable for export and international shipping?
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Yes, Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, including (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone.
How can I request a sample or a quote?
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Please contact our sales team via the website or direct email to request a sample or obtain a quotation for (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone.
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