(S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate
(S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate (CAS 51693-17-5), a chiral heterocyclic compound with the formula C12H15NO4S and a molecular weight of 269.32 g/mol. This tosylate salt is a valuable building block in asymmetric synthesis, particularly for the preparation of chiral amino acids and novel ligands used in enantioselective catalysis. Its defined stereochemistry makes it essential for producing stereochemically pure target molecules.
Synthesis of Chiral Amino Acids
This compound serves as a key intermediate in the stereoselective synthesis of (R)- and (S)-diaminovaleric acids, which are important chiral building blocks for peptides and pharmaceuticals.
Preparation of Chiral Ligands
It is utilised in the development of 5-azasemicorrin bidentate nitrogen ligands, which are critical for achieving high enantioselectivity in various catalytic transformations.
Asymmetric Synthesis
As a chiral building block, it enables the construction of complex chiral molecules by introducing specific stereocentres, crucial for drug discovery and development.
| Molecular weight | 269.32 |
|---|---|
| Empirical formula | C12H15NO4S |
| Assay | 95% |
| Optical activity | [α]20/D +8.5°, c = 1 in ethanol |
| Application | Serves as a building block in the synthesis of (R)- and (S)-diaminovaleric acids1 and of 5-azasemicorrin bidentate nitrogen ligands for enantioselective catalysis.2 |
| Melting point | 124-128 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate used for?
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This compound is used as a building block in asymmetric synthesis, including the preparation of chiral amino acids like (R)- and (S)-diaminovaleric acids and chiral ligands for enantioselective catalysis.
What is the CAS number and chemical formula for this compound?
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The CAS number is 51693-17-5 and the chemical formula is C12H15NO4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 95%. It is supplied for research and chemical synthesis purposes and is not represented as USP, EP, or BP grade.
How should this chemical be handled?
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This compound may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Use in a well-ventilated area with appropriate personal protective equipment including a dust mask (N95), eyeshields, and gloves.
Is this product available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including this product.
How can I request a quote or sample?
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Please contact our sales team via the website to request a quote or a sample for (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate.
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