m-Fluoro-L-phenylalanine
m-Fluoro-L-phenylalanine (CAS: 19883-77-3) is a fluorinated derivative of the essential amino acid phenylalanine, with the molecular formula C9H10FNO2 and a molecular weight of 183.18 g/mol. This unnatural amino acid is valuable in chemical biology and peptide chemistry for introducing fluorine into biomolecules. It serves as a key building block in chemical synthesis and is supplied by TSS for research and development purposes.
- IUPAC
- 3-Fluoro-L-phenylalanine
Chemical Biology Research
m-Fluoro-L-phenylalanine is used to incorporate fluorine into peptides and proteins, enabling studies on protein structure, function, and interactions using techniques like NMR spectroscopy. It acts as a probe for understanding biological processes at a molecular level.
Peptide Synthesis
This unnatural amino acid derivative is employed in solid-phase or solution-phase peptide synthesis to create modified peptides with altered pharmacokinetic or pharmacodynamic properties. Its incorporation can enhance metabolic stability or modify receptor binding.
Drug Discovery and Development
As a building block, m-Fluoro-L-phenylalanine aids in the synthesis of novel therapeutic candidates. Fluorine substitution can modulate a drug molecule's lipophilicity, metabolic stability, and binding affinity, which are critical factors in drug design.
Biochemical Studies
Researchers utilise m-Fluoro-L-phenylalanine to investigate enzyme mechanisms and metabolic pathways. Its presence can disrupt or alter normal biological processes, providing insights into enzyme kinetics and substrate specificities.
| Molecular weight | 183.18 |
|---|---|
| Empirical formula | C9H10FNO2 |
| Assay | ≥99.0% (sum of enantiomers, HPLC) |
| Optical activity | [α]20/D −25±2°, c = 1% in H2O |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is m-Fluoro-L-phenylalanine primarily used for?
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m-Fluoro-L-phenylalanine is primarily used in chemical biology and peptide chemistry as an unnatural amino acid for incorporating fluorine into biomolecules for research purposes, including structural studies and drug discovery.
What is the CAS number and molecular formula for m-Fluoro-L-phenylalanine?
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The CAS number for m-Fluoro-L-phenylalanine is 19883-77-3, and its molecular formula is C9H10FNO2.
What grade and purity does Tech Serve Solutions supply for m-Fluoro-L-phenylalanine?
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Tech Serve Solutions supplies m-Fluoro-L-phenylalanine with an assay of ≥99.0% (sum of enantiomers, HPLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should m-Fluoro-L-phenylalanine be handled safely?
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Appropriate safety measures include wearing eyeshields and gloves, and using a type N95 (US) or type P1 (EN143) respirator filter when handling m-Fluoro-L-phenylalanine, due to its potential hazards.
Can m-Fluoro-L-phenylalanine be exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including m-Fluoro-L-phenylalanine.
How can I request a sample or quote for m-Fluoro-L-phenylalanine?
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To request a sample or quote for m-Fluoro-L-phenylalanine, please contact our sales team through the TSS website or by calling our direct line.
What is the optical activity of m-Fluoro-L-phenylalanine?
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The optical activity of m-Fluoro-L-phenylalanine is [α]20/D −25±2°, measured at c = 1% in H2O.
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