(S)-(–)-3-3′-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1′-bi-2-naphthol
(S)-(–)-3-3′-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1′-bi-2-naphthol (CAS: 849939-13-5) is a chiral BINOL derivative with the molecular formula C36H18F12O2 and a molecular weight of 710.51 g/mol. This sophisticated organic compound serves as a crucial chiral ligand and catalyst in asymmetric synthesis. Its unique structure enables high enantioselectivity in various chemical transformations, making it invaluable for the preparation of chiral molecules.
- IUPAC
- (1S)-3,3′-Bis[3,5-bis(trifluoromethyl)phenyl]1,1′-binaphthalene-2,2′-diol
- Synonyms
- 849939-13-5C36H18F12O2(1S)-3,3′-Bis[3,5-bis(trifluoromethyl)phenyl]1,1′-binaphthalene-2,2′-diol
Chiral Ligand in Asymmetric Catalysis
This BINOL derivative acts as a highly effective chiral ligand, particularly in metal-catalyzed asymmetric reactions. It is employed to induce enantioselectivity, guiding the formation of one specific enantiomer over the other in the synthesis of complex chiral compounds.
Organocatalysis
Beyond its role in metal catalysis, the compound can function as an organocatalyst. Its chiral scaffold facilitates asymmetric transformations through non-metallic pathways, offering an alternative approach in stereoselective synthesis.
Synthesis of Pharmaceutical Intermediates
The high enantioselectivity achievable using this BINOL derivative makes it instrumental in the synthesis of chiral pharmaceutical intermediates. Precise control over stereochemistry is vital for drug efficacy and safety.
Materials Science Research
Chiral molecules are increasingly important in materials science. This compound can be explored for applications in areas requiring chiral recognition or specific optical properties, such as in chiral stationary phases for chromatography or in the development of chiral sensors.
| Molecular weight | 710.51 |
|---|---|
| Empirical formula | C36H18F12O2 |
| Assay | 95% |
| Optical activity | [α]22/D -56°, c = 1 in chloroform |
| Melting point | 215-219 °C |
Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(–)-3-3′-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1′-bi-2-naphthol used for?
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This compound is primarily used as a chiral ligand and catalyst in asymmetric synthesis, particularly in organocatalysis and metal-catalyzed reactions to achieve high enantioselectivity in the synthesis of chiral molecules and pharmaceutical intermediates.
What are the CAS number and formula for this chemical?
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The CAS number is 849939-13-5, and its empirical formula (Hill notation) is C36H18F12O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 95%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications.
How should this chemical be handled safely?
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This compound is classified as a Warning. It causes serious eye irritation (H319). When handling, wear a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation and avoid dust formation. In case of contact with eyes, rinse cautiously with water for several minutes (P305 + P351 + P338).
Is this chemical available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including (S)-(–)-3-3′-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1′-bi-2-naphthol. We handle international shipping and export procedures.
How can I request a quote or sample?
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To request a quote or a sample of (S)-(–)-3-3′-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1′-bi-2-naphthol, please contact our sales team through the website or by phone. Provide the product name and CAS number (849939-13-5) for efficient processing.
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