(S)-2-[(Diphenylphosphino)methyl]pyrrolidine
(S)-2-[(Diphenylphosphino)methyl]pyrrolidine (CAS 60261-46-3; C17H20NP) is a chiral organophosphorus compound. With a molecular weight of 269.32 g/mol, it serves as a crucial ligand in asymmetric synthesis. Its primary applications involve facilitating regioselective lactonization and asymmetric intramolecular allylation reactions, making it valuable in the development of complex organic molecules and pharmaceutical intermediates.
![(S)-2-[(Diphenylphosphino)methyl]pyrrolidine (C17H20NP) — chemical structure, CAS 60261-46-3; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F60261-46-3.png&w=3840&q=75)
Catalysis in Organic Synthesis
Functions as a key chiral ligand in metal-catalyzed reactions, enabling stereoselective transformations crucial for synthesizing complex organic molecules and pharmaceutical precursors.
Regioselective Lactonization
Employed in Ruthenium-catalyzed regioselective lactonization of unsymmetrical 1,4-diols, leading to the formation of lactone lignans.
Asymmetric Allylation Reactions
Utilised in the preparation of specific chiral compounds, such as vinylindanecarboxaldehyde, via asymmetric intramolecular allylation of propenylbenzenepropanal.
| Molecular weight | 269.32 |
|---|---|
| Empirical formula | C17H20NP |
| Density | 1.043 g/mL at 25 °C |
| Refractive index | n20/D 1.614 |
| Optical activity | [α]22/D −24.0°, c = 0.5 in ethanol |
| Application | Catalytic ligand in:• Ru-catalyzed regioselective lactonization of unsymmetrical 1,4-diols to give lactone lignans1• Preparation of vinylindanecarboxaldehyde by asymmetric intramolecular allylation of propenylbenzenepropanal2 |
| Flash point | >110 °C / >230 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-2-[(Diphenylphosphino)methyl]pyrrolidine used for?
+
(S)-2-[(Diphenylphosphino)methyl]pyrrolidine is primarily used as a chiral ligand in asymmetric synthesis, notably in catalytic reactions like regioselective lactonization and asymmetric allylation.
What are the CAS number and chemical formula for (S)-2-[(Diphenylphosphino)methyl]pyrrolidine?
+
The CAS number is 60261-46-3, and the chemical formula is C17H20NP.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this compound for research and development purposes. We do not represent it as USP/BP/EP or any other pharmacopoeia grade. Please refer to the Certificate of Analysis for specific purity details.
What are the safety and handling considerations for this chemical?
+
This compound has a flash point greater than 110 °C (230 °F) and a WGK rating of 3, indicating it is hazardous to water. Handle with appropriate personal protective equipment in a well-ventilated area. Consult the Safety Data Sheet for detailed information.
How is (S)-2-[(Diphenylphosphino)methyl]pyrrolidine packed and shipped?
+
Tech Serve Solutions carefully packs and ships fine chemicals globally, adhering to all relevant transport regulations. We provide comprehensive export documentation.
How can I request a sample or quote for (S)-2-[(Diphenylphosphino)methyl]pyrrolidine?
+
You can request a sample or quote by contacting our sales team directly through our website or by calling us. Please provide the product name and CAS number for prompt service.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis