(S)-2-[2-[Bis(2-tolyl)phosphino]phenyl]-4-tert-butyl-2-oxazoline
(S)-2-[2-[Bis(2-tolyl)phosphino]phenyl]-4-tert-butyl-2-oxazoline (CAS: 218460-00-5) is a chiral phosphine-oxazoline ligand with the empirical formula C27H30NOP. This highly effective ligand is primarily employed in asymmetric synthesis, catalysing various enantioselective transformations. Its unique structure enables precise control over stereochemistry, making it a valuable tool in the synthesis of complex chiral molecules for pharmaceutical and fine chemical industries.
- IUPAC
- (S)-2-[2-[Bis(2-tolyl)phosphino]phenyl]-4-tert-butyl-4,5-dihydro-oxazole
![(S)-2-[2-[Bis(2-tolyl)phosphino]phenyl]-4-tert-butyl-2-oxazoline (C27H30NOP) — chemical structure, CAS 218460-00-5; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F218460-00-5.png&w=3840&q=75)
Asymmetric Catalysis
This phosphine-oxazoline ligand is extensively used as a chiral catalyst in various enantioselective reactions. It facilitates the formation of specific stereoisomers, which is crucial for the synthesis of active pharmaceutical ingredients and other high-value chiral compounds.
Organic Synthesis
It serves as a key reagent in sophisticated organic synthesis, enabling chemists to construct complex molecular architectures with high stereochemical control. Its application is vital in research and development for novel compound discovery and process optimisation.
Ligand for Metal Complexes
This compound functions as a privileged ligand, readily forming catalytically active metal complexes. These complexes are instrumental in catalysing a range of asymmetric transformations, including hydrogenation, allylic alkylation, and Diels-Alder reactions.
| Empirical formula | C27H30NOP |
|---|---|
| Assay | 97% |
| Optical activity | [α]22/D −69.0, c = 1 in chloroform |
| Storage temperature | −20°C |
| Melting point | 134-138 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-2-[2-[Bis(2-tolyl)phosphino]phenyl]-4-tert-butyl-2-oxazoline used for?
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This compound is primarily used as a chiral ligand in asymmetric catalysis and organic synthesis for the enantioselective formation of chiral molecules.
What are the CAS number and formula for this chemical?
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The CAS number is 218460-00-5, and the empirical formula is C27H30NOP.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 97%. We do not represent this product as USP, BP, or EP grade; it is suitable for research and chemical synthesis applications.
How should (S)-2-[2-[Bis(2-tolyl)phosphino]phenyl]-4-tert-butyl-2-oxazoline be handled?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound has a WGK rating of 3 in Germany, indicating it is hazardous.
Is this chemical suitable for storage at low temperatures?
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Yes, the recommended storage temperature is −20°C to ensure stability and longevity of the compound.
How is this product packed, shipped, and exported?
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Tech Serve Solutions professionally packs and securely ships this chemical globally, adhering to all relevant international regulations for hazardous materials export.
How can I request a quote or sample?
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Please contact our sales team via the website or direct email to request a quotation or a sample for evaluation.
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