(S)-(−)-1-Chloro-3-(4-fluorophenoxy)-2-propanol
(S)-(−)-1-Chloro-3-(4-fluorophenoxy)-2-propanol (CAS: 352530-45-1; Formula: FC6H4OCH2CH(OH)CH2Cl; MW: 204.63) is a chiral alcohol featuring a fluorinated aryl ether moiety and a reactive chloromethyl group. This unique structure makes it a valuable building block in asymmetric synthesis and organic fluorinated compound development. It is primarily utilised in the synthesis of complex organic molecules, particularly where stereochemical control and the incorporation of a fluorophenoxy group are critical.
Chiral Synthesis
This compound serves as a crucial chiral building block in stereoselective synthesis. Its defined stereochemistry allows for the construction of enantiomerically pure target molecules, essential in pharmaceutical research and development.
Fluorinated Compound Development
The presence of the 4-fluorophenoxy group makes it a useful intermediate for introducing fluorinated aryl moieties into organic structures. Fluorine incorporation can significantly alter the physical and biological properties of molecules.
Pharmaceutical Intermediates
It can be employed in the multi-step synthesis of active pharmaceutical ingredients (APIs), where precise molecular architecture and chirality are paramount for biological activity.
Organic Building Block
As a versatile organic building block, it offers multiple reaction sites for further functionalisation, enabling the creation of a diverse range of complex organic molecules for various chemical research applications.
| Molecular weight | 204.63 |
|---|---|
| Linear formula | FC6H4OCH2CH(OH)CH2Cl |
| Assay | 97% |
| Boiling point | 283-284 °C(lit.) |
| Density | 1.28 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.522(lit.) |
| Optical activity | [α]20/D −0.25°, c = 1 in chloroform |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(−)-1-Chloro-3-(4-fluorophenoxy)-2-propanol primarily used for?
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It is primarily used as a chiral building block in asymmetric synthesis and for the development of organic fluorinated compounds, particularly in the pharmaceutical industry.
What is the CAS number and chemical formula for this product?
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The CAS number is 352530-45-1 and the chemical formula is FC6H4OCH2CH(OH)CH2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 97%. This product is not represented as USP, BP, EP, or other pharmacopoeia grades.
What are the safety and handling considerations for this chemical?
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Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, should be used. It has a flash point of 110 °C (230 °F). Consult the Safety Data Sheet for detailed handling and hazard information.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, adhering to all necessary regulations for safe and compliant shipping.
How can I request a sample or quote for (S)-(−)-1-Chloro-3-(4-fluorophenoxy)-2-propanol?
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Please contact our sales team or use the online request form to obtain a sample or a quote.
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