(S)-(−)-1,2,3,4-Tetrahydro-α,α-diphenyl-3-isoquinolinemethanol
(S)-(−)-1,2,3,4-Tetrahydro-α,α-diphenyl-3-isoquinolinemethanol (CAS: 140408-82-8), with the molecular formula C22H21NO and a molecular weight of 315.41 g/mol, is a chiral building block used in asymmetric synthesis. Its specific stereochemistry makes it valuable for creating enantiomerically pure compounds. This heterocyclic compound serves as a key intermediate in complex organic synthesis and the development of novel chemical entities.
- Synonyms
- 4-Tetrahydro-α,α-diphenyl-3-isoquinolinemethanol140408-82-8C22H21NO

Asymmetric Synthesis
This chiral isoquinoline derivative is employed as a building block in stereoselective synthesis. It enables the construction of complex molecules with defined stereochemistry, crucial for pharmaceutical research and development.
Chiral Auxiliary
The compound can function as a chiral auxiliary, influencing the stereochemical outcome of reactions. Its application helps in obtaining specific enantiomers of target molecules with high optical purity.
Organic Synthesis Intermediate
As a heterocyclic building block, it is used in the synthesis of more complex organic structures. Its unique diphenylmethanol moiety offers specific reactivity profiles for various transformations.
| Molecular weight | 315.41 |
|---|---|
| Empirical formula | C22H21NO |
| Assay | 97% |
| Optical activity | [α]22/D −100°, c = 1 in methanol |
| Melting point | 104-107 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(−)-1,2,3,4-Tetrahydro-α,α-diphenyl-3-isoquinolinemethanol used for?
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It is primarily used as a chiral building block in asymmetric synthesis and as an intermediate in organic synthesis.
What are the CAS number and molecular formula?
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The CAS number is 140408-82-8, and the molecular formula is C22H21NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at an assay of 97%. We do not represent it as USP, BP, EP, or any pharmacopoeia grade.
How should (S)-(−)-1,2,3,4-Tetrahydro-α,α-diphenyl-3-isoquinolinemethanol be handled?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. This compound is a skin, eye, and respiratory irritant.
Is this product available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, and this product can be exported.
How can I request a sample or a quote?
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Please contact our sales department or use the online inquiry form on our website to request a sample or a quote for (S)-(−)-1,2,3,4-Tetrahydro-α,α-diphenyl-3-isoquinolinemethanol.
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