RuPhos Pd G3
RuPhos Pd G3 (CAS: 1445085-77-7) is a third-generation palladacycle catalyst developed by Buchwald, featuring a sophisticated ligand structure. With a molecular weight of 836.37 g/mol and an empirical formula of C43H56NO5PPdS, this palladium complex is primarily employed in advanced organic synthesis, particularly for facilitating challenging cross-coupling reactions. Its high efficacy makes it a valuable reagent for researchers and chemists in the pharmaceutical and fine chemical industries.
- IUPAC
- (2-Dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate,RuPhos-G3-Palladacycle,RuPhos-Pd-G3
- Synonyms
- (2-Dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonateRuPhos-G3-PalladacycleRuPhos-Pd-G3
Cross-Coupling Reactions
RuPhos Pd G3 serves as a highly effective catalyst for various palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura, Buchwald-Hartwig amination, and Sonogashira couplings. It is particularly noted for its ability to promote reactions involving sterically hindered substrates or challenging coupling partners.
Catalysis in Organic Synthesis
As a homogeneous palladium catalyst, this compound enables efficient C-C and C-N bond formation under mild conditions. Its advanced ligand design contributes to improved catalytic activity, selectivity, and turnover numbers in complex synthetic pathways.
Pharmaceutical Intermediate Synthesis
The compound is instrumental in the synthesis of complex organic molecules, including key intermediates for pharmaceutical active ingredients (APIs). Its reliability and performance support the development of novel therapeutic agents.
| Molecular weight | 836.37 |
|---|---|
| Empirical formula | C43H56NO5PPdS |
| Assay | 95% |
| Melting point | 188-196 °C (decomposition) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H412Harmful to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38-52/53 |
| Safety statements (S) | 26-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is RuPhos Pd G3 used for?
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RuPhos Pd G3 is primarily used as a highly active palladium catalyst for challenging cross-coupling reactions in organic synthesis, particularly in the development of pharmaceutical intermediates and complex organic molecules.
What are the CAS number and formula for RuPhos Pd G3?
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The CAS number for RuPhos Pd G3 is 1445085-77-7, and its empirical formula is C43H56NO5PPdS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies RuPhos Pd G3 with an assay of 95%. This is typically considered a research or technical grade, and TSS does not represent it as USP, BP, or EP grade.
What are the safety considerations for handling RuPhos Pd G3?
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RuPhos Pd G3 is classified as a Warning. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). It is also harmful to aquatic life with long-lasting effects (H412). Handle with appropriate personal protective equipment in a well-ventilated area, avoiding dust formation and release into the environment.
How is RuPhos Pd G3 packed and exported?
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RuPhos Pd G3 is carefully packed to maintain its integrity during transit. As a global supplier, Tech Serve Solutions has extensive experience in exporting chemicals worldwide, adhering to all relevant international shipping regulations.
How can I request a quote or sample for RuPhos Pd G3?
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To request a quote or a sample of RuPhos Pd G3, please visit the Tech Serve Solutions website or contact our sales team directly. Provide the product name and CAS number for prompt service.
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