Rotenone
Rotenone (CAS: 83-79-4; Formula: C23H22O6; MW: 394.42 g/mol) is a naturally occurring isoflavone compound. Known for its potent biological activity, Rotenone is primarily recognised as a selective inhibitor of mitochondrial complex I. This property makes it a valuable tool in biochemical research for studying cellular respiration, oxidative stress, and related pathways. Its applications extend to entomology as a natural insecticide and piscicide.
Biochemical Research Tool
Rotenone is widely employed in research laboratories to investigate mitochondrial function and oxidative phosphorylation. Its specific inhibition of Complex I allows scientists to study electron transport chain dynamics and the generation of reactive oxygen species.
Cellular Respiration Studies
By blocking mitochondrial Complex I, Rotenone serves as a critical reagent for elucidating the mechanisms of cellular respiration. Researchers use it to induce specific cellular states for the study of energy metabolism and cellular stress responses.
Neuroscience Research
In neuroscience, Rotenone is utilised to model Parkinsonism in experimental settings. Its ability to induce dopaminergic neurodegeneration in animal models aids in understanding disease pathogenesis and testing potential therapeutic interventions.
Natural Insecticide and Piscicide
Historically, Rotenone has been used as a botanical insecticide and piscicide due to its toxicity to insects and fish. Its application in this area is subject to regulatory restrictions in many regions.
| Molecular weight | 394.42 |
|---|---|
| Empirical formula | C23H22O6 |
| Assay | ≥95% |
| Boiling point | 210-220 °C/0.5 mmHg(lit.) |
| Melting point | 159-164 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P301IF SWALLOWED
- P305IF IN EYES
- P501Dispose of contents and container per local regulations
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 25-36/37/38-50/53 |
| Safety statements (S) | 22-24/25-36-45-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Rotenone primarily used for?
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Rotenone (CAS: 83-79-4) is primarily used as a research tool to study mitochondrial respiration, cellular energy metabolism, and to model neurodegenerative conditions like Parkinson's disease. It is also known for its insecticidal and piscicidal properties.
What are the CAS number and chemical formula for Rotenone?
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The CAS number for Rotenone is 83-79-4, and its chemical formula is C23H22O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Rotenone with an assay of ≥95%. This product is suitable for research and laboratory use. We do not represent this product as USP, BP, or EP grade.
How should Rotenone be handled safely?
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Rotenone is a dangerous substance. It is toxic if swallowed, causes skin irritation, and serious eye irritation, and may cause respiratory irritation. It is also very toxic to aquatic life with long-lasting effects. Always handle with appropriate personal protective equipment, in a well-ventilated area, and avoid release into the environment.
Is Rotenone a controlled substance?
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The provided data does not indicate that Rotenone is a controlled substance. However, its use as an insecticide and piscicide may be regulated in certain jurisdictions.
How is Rotenone packed, shipped, and exported by TSS?
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Rotenone is packed according to appropriate safety and regulatory standards for hazardous materials. Tech Serve Solutions exports globally, adhering to all relevant international shipping regulations for chemicals.
How can I request a quote or sample of Rotenone?
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To request a quote or sample of Rotenone, please use the contact form on our website or contact our sales department directly with your specific requirements.
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