2,4,6-Triisopropylbenzenesulfonyl chloride
2,4,6-Triisopropylbenzenesulfonyl chloride (CAS 6553-96-4) is a versatile organic building block with the linear formula [(CH3)2CH]3C6H2SO2Cl and a molecular weight of 302.86. This sulfonyl halide is employed in various chemical synthesis applications, including the formation of coupling reagents for oligonucleotide synthesis and the preparation of sulfonates. Its distinct structure makes it valuable in specialised analytical techniques and organic chemistry research.
- Synonyms
- 6553-96-4[(CH3)2CH]3C6H2SO2Cl
![2,4,6-Triisopropylbenzenesulfonyl chloride ([(CH3)2CH]3C6H2SO2Cl) — chemical structure, CAS 6553-96-4; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F6553-96-4.png&w=3840&q=75)
Phospholipid Analysis
2,4,6-Triisopropylbenzenesulfonyl chloride has been utilised in the High-Performance Liquid Chromatography/Mass Spectrometry (HPLC/MS) analysis of phosphonolipids found in eggyolk.
Oligonucleotide Synthesis
This compound serves as a precursor for coupling reagents critical in the synthesis of oligonucleotides, a key area in molecular biology and diagnostics.
Synthesis of Neomycin Conjugates
It has been used in the preparation of dimeric neomycin-neomycin conjugates, specifically those featuring a flexible linker such as 2,2′-(ethylenedioxy)bis(ethylamine).
Preparation of Sulfonates
The reagent is instrumental in the synthesis of sulfonates derived from pyrimidine nucleosides, contributing to the development of novel nucleoside analogues.
| Molecular weight | 302.86 |
|---|---|
| Linear formula | [(CH3)2CH]3C6H2SO2Cl |
| Assay | 97% |
| Solubility | ethanol: soluble5%, clear, colorless to light yellow |
| Application | 2,4,6-Triisopropylbenzenesulfonyl chloride was used in analysis of phosphonolipids in eggyolk by HPLC/MS technique1. It was used in the synthesis of :• dimeric neomycin-neomycin conjugate with a flexible linker, 2,2′-(ethylenedioxy)bis(ethylamine)2• coupling reagents for the synthesis of oligonucleotides3,4• sulfonates of pyrimidine nucleosides5 |
| Melting point | 92-94 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4,6-Triisopropylbenzenesulfonyl chloride used for?
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2,4,6-Triisopropylbenzenesulfonyl chloride is used in chemical synthesis, particularly for preparing coupling reagents in oligonucleotide synthesis, as a reagent in phospholipid analysis, and in the synthesis of neomycin conjugates and pyrimidine nucleoside sulfonates.
What is the CAS number and chemical formula for 2,4,6-Triisopropylbenzenesulfonyl chloride?
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The CAS number is 6553-96-4, and the linear formula is [(CH3)2CH]3C6H2SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4,6-Triisopropylbenzenesulfonyl chloride with an assay of 97%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety precautions for handling 2,4,6-Triisopropylbenzenesulfonyl chloride?
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This compound is a Danger substance classified under GHS05, carrying the hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection (type N100 US or P3 EN143), must be used. Handle with extreme caution in a well-ventilated area.
How is 2,4,6-Triisopropylbenzenesulfonyl chloride packed, shipped, and exported?
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2,4,6-Triisopropylbenzenesulfonyl chloride is packed in compliance with UN 3261 8 / PGII regulations for hazardous materials. Tech Serve Solutions, established in 1998, is an experienced global supplier and exporter of fine chemicals.
How can I request a sample or a quote for 2,4,6-Triisopropylbenzenesulfonyl chloride?
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To request a sample or a quote, please contact our sales department through the provided channels on the Tech Serve Solutions website. Specify the product name and CAS number (6553-96-4) in your enquiry.
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