(R)-(−)-tert-Leucinol
(R)-(−)-tert-Leucinol (CAS: 112245-09-7), a chiral amino alcohol with the linear formula (CH3)3CCH(NH2)CH2OH and a molecular weight of 117.19 g/mol, is a valuable building block in organic synthesis. It serves as a key intermediate in the preparation of chiral ligands, catalysts, and pharmaceutical compounds. Its unique structure, derived from tert-leucine, makes it particularly useful for asymmetric synthesis applications in chemical biology and peptide chemistry.
- IUPAC
- (R)-2-Amino-3,3-dimethyl-1-butanol
- Synonyms
- (R)-2-Amino-3,3-dimethyl-1-butanol
Chiral Auxiliary in Asymmetric Synthesis
This enantiomerically pure amino alcohol functions as a chiral auxiliary, enabling the stereoselective synthesis of complex organic molecules. It is frequently employed in asymmetric alkylations, reductions, and Diels-Alder reactions.
Ligand Synthesis for Catalysis
(R)-(−)-tert-Leucinol is a precursor for various chiral ligands, including phosphines and oxazolines. These ligands are crucial for developing highly enantioselective transition metal catalysts used in pharmaceutical and fine chemical manufacturing.
Peptide Chemistry
As an amino alcohol derivative, it finds application in the synthesis of non-natural amino acids and modified peptides. Its incorporation can influence peptide conformation and biological activity.
Research and Development
It is widely used in academic and industrial research laboratories for exploring new synthetic methodologies and developing novel biologically active compounds.
| Molecular weight | 117.19 |
|---|---|
| Linear formula | (CH3)3CCH(NH2)CH2OH |
| Assay | 98% |
| Boiling point | 70 °C/0.4 mmHg(lit.) |
| Density | 0.9 g/mL at 25 °C(lit.) |
| Optical activity | [α]20/D −37°, c = 1.5 in ethanol |
| Melting point | 30-33 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 90 °C / 194 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-tert-Leucinol used for?
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(R)-(−)-tert-Leucinol is primarily used as a chiral auxiliary and building block in asymmetric synthesis, for the preparation of chiral ligands, and in peptide chemistry.
What are the CAS number and chemical formula for (R)-(−)-tert-Leucinol?
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The CAS number is 112245-09-7 and the linear formula is (CH3)3CCH(NH2)CH2OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(−)-tert-Leucinol with an assay of 98%. This product is intended for research and chemical synthesis purposes and is not supplied as USP, EP, or BP grade.
What are the key safety considerations when handling (R)-(−)-tert-Leucinol?
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This compound is a Warning-classified chemical (GHS07) with hazards H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Ensure adequate ventilation, wear a dust mask (N95), eyeshields, and gloves. Handle with care to avoid dust formation and inhalation.
How is (R)-(−)-tert-Leucinol packed and shipped?
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Tech Serve Solutions packs and ships fine chemicals, including (R)-(−)-tert-Leucinol, adhering to international shipping regulations for chemical products. We export globally.
How can I request a quote or sample for (R)-(−)-tert-Leucinol?
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To request a quote or a sample of (R)-(−)-tert-Leucinol, please visit the product page on our website and use the designated 'Request Quote' or 'Request Sample' function, or contact our sales department directly.
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