R-MOP
R-MOP (CAS: 145964-33-6), with the molecular formula C33H25OP and a molecular weight of 468.52 g/mol, is a chiral phosphine ligand. It is primarily utilised in asymmetric synthesis for catalysing various stereoselective transformations. This compound plays a critical role in palladium-catalyzed hydrosilylation, reduction reactions, and rhodium-catalyzed additions, contributing to the efficient synthesis of enantiomerically enriched products.
- IUPAC
- (R)-(+)-2-(Diphenylphosphino)-2′-methoxy-1,1′-binaphthyl
Asymmetric Hydrosilylation
R-MOP serves as a ligand in palladium-catalyzed asymmetric hydrosilylation of olefins. This application is crucial for introducing chirality into organic molecules with high enantioselectivity.
Asymmetric Reduction Reactions
This ligand is employed in palladium-catalyzed reduction of allylic esters. It facilitates stereoselective hydrogenolysis, a key step in the synthesis of chiral intermediates.
Asymmetric Addition Reactions
In rhodium-catalyzed asymmetric addition reactions, R-MOP acts as a chiral ligand, directing the stereochemical outcome of the reaction and enabling the formation of specific enantiomers.
Asymmetric Amination
R-MOP is also utilised in asymmetric amination reactions catalysed by copper(I) complexes. This broadens its utility in constructing chiral amines, which are prevalent in pharmaceuticals.
| Molecular weight | 468.52 |
|---|---|
| Empirical formula | C33H25OP |
| Assay | ≥94% |
| Optical activity | [α]20/D +94°, c = 0.5 in chloroform |
| Application | Takasago Ligands and Complexes for Asymmetric ReactionsLigand used in palladium-catalyzed asymmetric hydrosilylation of olefins1,2, palladium-catalyzed reduction of allylic esters3, rhodium-catalyzed asymmetric addition reactions4,5, and asymmetric amination reactions catalyzed by copper(I) complexes6. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is R-MOP used for?
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R-MOP is a chiral phosphine ligand used in asymmetric synthesis for palladium-catalyzed hydrosilylation and reduction of allylic esters, rhodium-catalyzed additions, and copper-catalyzed asymmetric amination reactions.
What are the CAS number and formula for R-MOP?
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The CAS number for R-MOP is 145964-33-6, and its empirical formula is C33H25OP.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies R-MOP with an assay of ≥94%. This product is not classified as USP, BP, or EP grade.
What are the safety considerations for handling R-MOP?
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Handling R-MOP requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. R-MOP is classified as WGK 3 in Germany, indicating a high hazard to water.
How is R-MOP packed, shipped, and exported?
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Tech Serve Solutions ensures secure and compliant packing for R-MOP, adhering to international shipping and export regulations for fine chemicals.
How can I request a sample or quote for R-MOP?
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To request a sample or quote for R-MOP, please contact our sales team through the website or directly via email or phone.
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