Bis(2,2,2-trifluoroethyl) phosphite
Bis(2,2,2-trifluoroethyl) phosphite (CAS 92466-70-1), a clear liquid with the molecular formula (CF3CH2O)2P(O)H and a molecular weight of 246.04 g/mol, serves as a valuable building block in organic synthesis. Its chemical structure, featuring trifluoroethoxy groups attached to a phosphite core, enables its use in the preparation of various organophosphorus compounds. This reagent is primarily employed in research and development settings for chemical synthesis.
- IUPAC
- Phosphonic acid bis(2,2,2-trifluoroethyl) ester
- Synonyms
- 92466-70-1(CF3CH2O)2P(O)HPhosphonic acid bis(2,2,2-trifluoroethyl) ester

Organic Synthesis Reagent
Bis(2,2,2-trifluoroethyl) phosphite is utilised as a reagent in organic synthesis. It acts as a precursor for the introduction of phosphite functionalities into organic molecules, facilitating the construction of complex structures.
Preparation of Organophosphorus Compounds
This phosphite ester is a useful intermediate for synthesising a range of organophosphorus compounds. Its specific reactivity allows for targeted modifications in the development of novel chemical entities.
Research and Development
Applied in R&D laboratories, Bis(2,2,2-trifluoroethyl) phosphite aids in exploring new synthetic pathways and developing innovative chemical processes. Its properties are of interest for academic and industrial research.
| Molecular weight | 246.04 |
|---|---|
| Linear formula | (CF3CH2O)2P(O)H |
| Assay | 90% |
| Boiling point | 43-44 °C/2 mmHg(lit.) |
| Density | 1.545 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.332(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 76 °C / 168.8 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 23-26-28-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(2,2,2-trifluoroethyl) phosphite used for?
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Bis(2,2,2-trifluoroethyl) phosphite is primarily used as a building block in organic synthesis and for the preparation of organophosphorus compounds in research and development settings.
What is the CAS number and formula for Bis(2,2,2-trifluoroethyl) phosphite?
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The CAS number is 92466-70-1 and the linear formula is (CF3CH2O)2P(O)H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bis(2,2,2-trifluoroethyl) phosphite with an assay of 90%. We do not represent this product as USP, BP, or EP grade.
How should Bis(2,2,2-trifluoroethyl) phosphite be handled?
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Handle with appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation. Avoid contact with skin, eyes, and clothing, and avoid breathing vapour. This compound may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335).
Is Bis(2,2,2-trifluoroethyl) phosphite shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Bis(2,2,2-trifluoroethyl) phosphite.
How can I request a quote or sample?
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To request a quote or sample of Bis(2,2,2-trifluoroethyl) phosphite, please contact our sales team via the website or direct inquiry.
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