(R)-Boc-2-(trifluoromethyl)-β-Phe-OH
(R)-Boc-2-(trifluoromethyl)-β-Phe-OH (CAS: 501015-17-4) is a chiral trifluoromethylated phenylalanine derivative with the molecular formula C15H18F3NO4 and a molecular weight of 333.30 g/mol. This unnatural beta-amino acid finds utility in chemical synthesis and peptide chemistry. Its trifluoromethyl group and beta-amino acid structure make it a valuable building block for creating novel peptides and peptidomimetics with modified properties.
- IUPAC
- (R)-3-(Boc-amino)-3-[2-(trifluoromethyl)phenyl]propionic acid,Boc-2-(trifluoromethyl)-L-β-phenylalanine

Peptide Synthesis
Incorporated into peptide chains to introduce conformational constraints or alter pharmacokinetic properties due to the trifluoromethyl and beta-amino acid features.
Chemical Biology Research
Utilised as a building block for the synthesis of complex molecules and probes for studying biological systems, particularly where modified amino acids are required.
Drug Discovery
Serves as a key intermediate in the development of novel therapeutic agents, leveraging its unique structural characteristics to design compounds with enhanced efficacy or stability.
Organic Synthesis
Employed as a chiral synthon in asymmetric synthesis for the construction of stereochemically defined organic compounds.
| Molecular weight | 333.30 |
|---|---|
| Empirical formula | C15H18F3NO4 |
| Assay | ≥98.0% (HPLC) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-Boc-2-(trifluoromethyl)-β-Phe-OH used for?
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This compound is primarily used in peptide synthesis, chemical biology research, drug discovery, and organic synthesis as a chiral building block.
What is the CAS number and formula for (R)-Boc-2-(trifluoromethyl)-β-Phe-OH?
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The CAS number is 501015-17-4 and the empirical formula is C15H18F3NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-Boc-2-(trifluoromethyl)-β-Phe-OH with an assay of ≥98.0% (HPLC). TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should (R)-Boc-2-(trifluoromethyl)-β-Phe-OH be handled?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The compound is classified under WGK Germany 3, indicating a high hazard to water.
Is (R)-Boc-2-(trifluoromethyl)-β-Phe-OH available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including (R)-Boc-2-(trifluoromethyl)-β-Phe-OH.
How can I request a quote or sample?
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Please contact our sales team to request a quote or to arrange for a sample of (R)-Boc-2-(trifluoromethyl)-β-Phe-OH.
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