(R)-(+)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane
(R)-(+)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane (CAS 57044-24-3), a chiral building block with molecular formula C6H11ClO2 and molar mass 150.60 g/mol, is essential in asymmetric synthesis. This protected alcohol derivative serves as a key intermediate in the preparation of complex organic molecules, including pharmaceuticals. Its specific stereochemistry makes it valuable for stereoselective chemical transformations.
- Synonyms
- 57044-24-3C6H11ClO2
Pharmaceutical Intermediate Synthesis
Utilised in the synthesis of active pharmaceutical ingredients (APIs). Notably, it serves as a precursor in the preparation of both enantiomers of ketoconazole, an antifungal medication.
Asymmetric Synthesis
Functions as a chiral building block, enabling the stereoselective construction of complex organic molecules where precise stereochemistry is critical.
Organic Synthesis
A versatile reagent in organic chemistry for introducing specific structural motifs and chirality into target compounds during multi-step synthetic routes.
| Molecular weight | 150.60 |
|---|---|
| Empirical formula | C6H11ClO2 |
| Assay | 98% |
| Boiling point | 63 °C/37 mmHg(lit.) |
| Density | 1.103 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.434(lit.) |
| Optical activity | [α]24/D +42.1°, neat |
| Application | Utilized in the preparation of both enantiomers of the orally active antifungal azolic agent ketoconazole.1 |
Hazard statements
- H226Flammable liquid and vapour
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 51 °C / 123.8 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-41 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane used for?
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(R)-(+)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane is primarily used in asymmetric synthesis and as a pharmaceutical intermediate, notably in the preparation of ketoconazole.
What is the CAS number and formula for this compound?
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The CAS number is 57044-24-3, and its empirical formula is C6H11ClO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of 98%. We do not represent it as USP, BP, or EP grade.
How should (R)-(+)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane be handled safely?
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This compound is a flammable liquid and causes serious eye damage. Handle with appropriate personal protective equipment, including eyeshields, face shields, and chemical-resistant gloves. Ensure adequate ventilation and avoid ignition sources.
Is this chemical controlled or scheduled?
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The provided data does not indicate that this chemical is a controlled substance.
How is this chemical packed and exported?
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Tech Serve Solutions exports fine chemicals globally, adhering to all relevant shipping regulations for hazardous materials. Specific packing details are available upon request.
How can I request a sample or quote?
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To request a sample or a quotation, please contact our sales team through the website or by phone, providing the product name and CAS number.
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