(R)-4-Chloro-α-methylbenzylamine
(R)-4-Chloro-α-methylbenzylamine (CAS: 27298-99-3; C8H10ClN) is a chiral organic amine and a valuable building block. With a molecular weight of 155.62 g/mol, this compound is characterised by its amine functionality and a chiral centre, making it indispensable in asymmetric synthesis. Its primary applications lie in the creation of complex molecules where stereochemical control is paramount, serving the pharmaceutical and fine chemical industries.
- IUPAC
- (R)-1-(4-Chlorophenyl)ethylamine
- Synonyms
- (R)-1-(4-Chlorophenyl)ethylamine
Chiral Building Block
This compound serves as a crucial chiral intermediate in the synthesis of enantiomerically pure pharmaceuticals and agrochemicals. Its defined stereochemistry allows for the precise construction of complex molecular architectures.
Asymmetric Synthesis
As a chiral amine, (R)-4-Chloro-α-methylbenzylamine is frequently employed as a resolving agent or a chiral auxiliary in asymmetric synthesis. It facilitates the selective formation of one enantiomer over the other.
Pharmaceutical Intermediates
It functions as a key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs). Its incorporation ensures the correct stereochemistry required for drug efficacy and safety.
Organic Synthesis
This chemical is a versatile reagent in general organic synthesis, enabling the introduction of a chiral chloro-substituted benzylamine moiety into various target molecules for research and development.
| Molecular weight | 155.62 |
|---|---|
| Empirical formula | C8H10ClN |
| Assay | ≥99%≥99.0% (GC) |
| Density | 1.110 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.543(lit.) |
| Optical purity | enantiomeric excess: ≥90.0% |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H318Causes serious eye damage
- H330Fatal if inhaled
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | 115 °C / 239 °F |
|---|---|
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 22-23-38-41-43-51/53 |
| Safety statements (S) | 26-36/37/39-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-4-Chloro-α-methylbenzylamine used for?
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(R)-4-Chloro-α-methylbenzylamine is used as a chiral building block and intermediate in asymmetric synthesis and the production of pharmaceuticals and fine chemicals.
What are the CAS and formula for (R)-4-Chloro-α-methylbenzylamine?
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The CAS number is 27298-99-3, and the empirical formula is C8H10ClN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-4-Chloro-α-methylbenzylamine with an assay of ≥99.0% (GC) and an optical purity (enantiomeric excess) of ≥90.0%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How is this chemical handled and what are the hazards?
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This compound is classified as Dangerous (GHS05, GHS06, GHS09) and carries the signal word 'Danger'. It is harmful if swallowed (H302), causes skin irritation (H315), may cause an allergic skin reaction (H317), causes serious eye damage (H318), is fatal if inhaled (H330), and is toxic to aquatic life with long-lasting effects (H411). Handle with appropriate personal protective equipment in a well-ventilated area. Refer to the Safety Data Sheet for detailed handling instructions.
How are your chemicals packed and exported?
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Chemicals are carefully packed according to international transport regulations, including UN 2810 6.1 / PGIII for this product. Tech Serve Solutions is a specialist global supplier and exporter, experienced in handling and shipping fine chemicals worldwide.
How can I request a sample or a quote?
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To request a sample or a quote for (R)-4-Chloro-α-methylbenzylamine, please contact our sales team through the website or by calling us. Please specify the quantity required.
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