(R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine
(R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine (CAS: 352535-00-3, Formula: C17H18FN) is a chiral pyrrolidine derivative with a molecular weight of 255.33 g/mol. This compound is recognised for its efficacy and excellent enantioselectivities as a catalyst in asymmetric synthesis, particularly in the enantioselective Weitz-Scheffer epoxidation of alpha,beta-unsaturated aldehydes. It is available in both enantiomeric forms and facilitates operationally simple transformations.
Asymmetric Epoxidation
This compound serves as a highly efficient catalyst for the enantioselective Weitz-Scheffer epoxidation of alpha,beta-unsaturated aldehydes, yielding products with excellent enantioselectivities. It allows for operationally simple transformations in synthetic routes.
Chiral Amine Catalyst
As a chiral pyrrolidine, it can participate in catalytic cycles where its stereochemistry dictates the enantiomeric outcome of reactions. The specific structure enables predictable spatial orientation of reaction intermediates.
Fluorinated Building Block
Its structure, featuring a fluorodiphenylmethyl moiety attached to a pyrrolidine ring, makes it a valuable building block for introducing chirality and fluorine into complex organic molecules.
| Molecular weight | 255.33 |
|---|---|
| Empirical formula | C17H18FN |
| Assay | 97% |
| Density | 1.098 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.577(lit.) |
| Optical activity | [α]20/D +25°, c = 1 in chloroform |
| Optical purity | ee: 98% (HPLC) |
| Application | Features:• Highly efficient• Excellent enantioselectivities• Available in both enantiomers• Operationally simple transformationsCatalyst for the enantioselective Weitz-Scheffer epoxidation of α,β-unsaturated aldehydes.1Condensation of this secondary amine with an aldehyde reversibly generates a β-fluoroiminium species where the fluorine atom is positioned gauche to the electropositive nitrogen centre.2Consequently, the phenyl substituents on the fluorine bearing carbon are placed in a predictable region of space. One of the groups effectively shields the upper face of the pendant iminium chain.R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine Scheme 1\" title=\"(R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine Scheme 1\">Addition of hydrogen peroxide occurs in a highly selective manner t |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 63 °C / 145.4 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine used for?
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(R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine is primarily used as a catalyst in asymmetric synthesis, notably for the enantioselective Weitz-Scheffer epoxidation of alpha,beta-unsaturated aldehydes.
What are the CAS number and formula for (R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine?
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The CAS number is 352535-00-3, and the empirical formula is C17H18FN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine with an assay of 97% and an optical purity of >=98% ee. TSS does not represent this product as USP, BP, or EP grade.
How should (R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine be handled safely?
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This compound is a Warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, should be worn, and handling should occur in a well-ventilated area or with a suitable respirator.
How is (R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine packed and shipped?
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(R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine is classified under NA 1993 / PGIII and is available for export by Tech Serve Solutions.
How can I request a quote or sample?
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To request a quote or a sample of (R)-(+)-2-(Fluorodiphenylmethyl)pyrrolidine, please contact our sales team via the website or direct email.
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