(R)-(−)-2-Amino-3-methylbutane
(R)-(−)-2-Amino-3-methylbutane (CAS: 34701-33-2, Formula: C5H13N) is a chiral amine with a molecular weight of 87.16 g/mol. This valuable organic building block plays a crucial role in asymmetric synthesis. It is widely employed as a chiral auxiliary or resolving agent in the preparation of enantiomerically pure compounds, particularly in the pharmaceutical and fine chemical industries. Its specific stereochemistry makes it indispensable for creating complex chiral molecules.
- IUPAC
- (R)-(−)-3-Methyl-2-butylamine
- Synonyms
- (R)-(−)-3-Methyl-2-butylamine
Chiral Auxiliary in Asymmetric Synthesis
As a chiral auxiliary, (R)-(−)-2-Amino-3-methylbutane can be temporarily incorporated into a molecule to direct the stereochemical outcome of a reaction. After the desired stereochemistry is established, the auxiliary is cleaved, leaving behind an enantiomerically enriched product.
Resolving Agent for Racemates
This chiral amine can be used to resolve racemic mixtures of acidic compounds. By forming diastereomeric salts, which have different physical properties, the enantiomers can be separated through methods like fractional crystallization.
Synthesis of Chiral Ligands
It serves as a fundamental building block for the synthesis of more complex chiral ligands used in asymmetric catalysis. These ligands are essential for developing highly enantioselective catalytic processes.
Pharmaceutical Intermediate
The compound is valuable in the multi-step synthesis of active pharmaceutical ingredients (APIs) and other biologically relevant molecules where specific stereochemistry is critical for efficacy and safety.
| Molecular weight | 87.16 |
|---|---|
| Empirical formula | C5H13N |
| Assay | ≥97.0% (GC) |
| Density | 0.75 g/mL at 20 °C(lit.) |
| Optical activity | [α]/D −5.5±1°, neat |
Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 2733 3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-2-Amino-3-methylbutane used for?
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(R)-(−)-2-Amino-3-methylbutane is primarily used as a chiral building block in asymmetric synthesis, acting as a chiral auxiliary or resolving agent for the preparation of enantiomerically pure compounds, particularly in the pharmaceutical and fine chemical industries.
What is the CAS number and chemical formula?
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The CAS number for (R)-(−)-2-Amino-3-methylbutane is 34701-33-2, and its empirical formula is C5H13N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(−)-2-Amino-3-methylbutane with an assay of ≥97.0% (GC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated. It is suitable for research and general chemical synthesis purposes.
How should (R)-(−)-2-Amino-3-methylbutane be handled safely?
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(R)-(−)-2-Amino-3-methylbutane is a flammable liquid and vapour (H225), harmful if swallowed (H302), causes severe skin burns and eye damage (H314), and is toxic if inhaled (H331). Handle with appropriate personal protective equipment, including gloves, goggles, and respiratory protection, in a well-ventilated area, away from ignition sources.
Is this compound a controlled substance?
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Based on the provided safety data, (R)-(−)-2-Amino-3-methylbutane is not indicated as a controlled or scheduled substance.
How is (R)-(−)-2-Amino-3-methylbutane packaged and shipped?
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This product is shipped according to international regulations for hazardous materials (UN 2733, Class 3, Packing Group II). Packaging is designed to ensure safety and product integrity during transport and export.
How can I request a sample or quote?
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To request a sample or a quotation for (R)-(−)-2-Amino-3-methylbutane, please contact our sales department through the website or via email, providing your specific requirements.
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