4-Methoxyphenyl isocyanate
4-Methoxyphenyl isocyanate (CAS: 5416-93-3) is an organic compound with the formula CH3OC6H4NCO and a molecular weight of 149.15 g/mol. This isocyanate serves as a valuable building block in organic synthesis. Its reactivity makes it suitable for the preparation of various heterocyclic compounds and complex organic molecules in research and development settings.
Synthesis of Heterocyclic Compounds
4-Methoxyphenyl isocyanate is employed in the synthesis of novel heterocyclic systems, such as 6H-indolo[2,3-b]quinolines. These structures are of interest in medicinal chemistry and materials science.
Preparation of Substituted Ureas
The compound is utilised in the preparation of substituted ureas. For example, it has been used in the synthesis of complex pyrazolotriazolopyrimidine derivatives with potential biological activities.
Organic Synthesis Building Block
As a functionalised isocyanate, it acts as a versatile reagent for introducing the 4-methoxyphenylcarbamoyl group into organic molecules, facilitating the construction of diverse chemical architectures.
| Molecular weight | 149.15 |
|---|---|
| Linear formula | CH3OC6H4NCO |
| Assay | 99% |
| Boiling point | 106-110 °C/16 mmHg(lit.) |
| Density | 1.151 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.548(lit.) |
| Application | 4-Methoxyphenyl isocyanate has been used in the preparation of:• 6H-indolo[2,3-b]quinolines1• 1-[2-(2-furyl)-8-methyl-9-substituted-8H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c] pyrimidin-5-yl]-3-(4-methoxyphenyl)urea2 |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 20/21/22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methoxyphenyl isocyanate used for?
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4-Methoxyphenyl isocyanate is primarily used as a building block in organic synthesis for the preparation of heterocyclic compounds and substituted ureas.
What are the CAS number and chemical formula for 4-Methoxyphenyl isocyanate?
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The CAS number is 5416-93-3 and the chemical formula is CH3OC6H4NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions typically supplies 4-Methoxyphenyl isocyanate with an assay of 99%. This is generally considered a technical or research grade, and TSS does not represent it as USP, BP, or EP grade unless explicitly stated.
What are the main safety hazards associated with 4-Methoxyphenyl isocyanate?
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4-Methoxyphenyl isocyanate is classified as Danger and carries hazard statements H302, H312, H314, and H332, indicating it is harmful if swallowed, in contact with skin, and if inhaled, and causes severe skin burns and eye damage. Appropriate personal protective equipment, including gloves, goggles, and respiratory protection, is essential.
How is 4-Methoxyphenyl isocyanate packed, shipped, and exported?
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4-Methoxyphenyl isocyanate is packed and shipped in accordance with international regulations for hazardous materials. TSS is an experienced global supplier and exporter of fine chemicals.
How can I request a sample or quote for 4-Methoxyphenyl isocyanate?
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Please contact our sales team directly through the website or by phone to request a sample or a formal quotation for 4-Methoxyphenyl isocyanate.
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