(R)-(+)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine
(R)-(+)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine (CAS 221012-82-4) is a chiral phosphine ligand with the molecular formula C38H34N2O4P2 and a molecular weight of 644.64 g/mol. This highly effective P-Phos ligand is primarily utilised in asymmetric synthesis and catalysis, particularly for asymmetric hydrogenation reactions, enabling the selective formation of chiral products.
- IUPAC
- (R)-P-Phos
- Synonyms
- 6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine221012-82-4C38H34N2O4P2(R)-P-Phos

Asymmetric Hydrogenation
This ligand is employed in asymmetric hydrogenation reactions, facilitating the stereoselective reduction of unsaturated substrates to produce enantiomerically enriched compounds.
Chiral Catalysis
As a key component in chiral catalyst systems, it enables asymmetric transformations crucial for the synthesis of complex molecules, including pharmaceutical intermediates.
Ligand in Organometallic Chemistry
It functions as a privileged bidentate phosphine ligand, coordinating with transition metals to form active catalytic species for various organic transformations.
| Molecular weight | 644.64 |
|---|---|
| Empirical formula | C38H34N2O4P2 |
| Assay | 97% |
| Optical activity | [α]20/D +98°, c = 1 in chloroform |
| Application | Ligand employed in the asymmetic hydrogenation of |
| Melting point | 261-265 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine used for?
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(R)-(+)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine is primarily used as a chiral ligand in asymmetric synthesis, particularly for asymmetric hydrogenation reactions.
What is the CAS number and molecular formula?
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The CAS number is 221012-82-4 and the molecular formula is C38H34N2O4P2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of 97%. We do not represent it as USP, BP, or EP grade.
What are the safety and handling precautions for this chemical?
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This compound is classified under WGK Germany 3, indicating it is hazardous to water. Please consult the Safety Data Sheet (SDS) for comprehensive handling and safety information.
How is this product packed and shipped?
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This product is carefully packed and exported by Tech Serve Solutions, adhering to all relevant regulations for chemical transport.
How can I request a sample or quote?
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To request a sample or a quotation, please contact our sales team through the website or by phone.
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