(R)-(−)-1-Methyl-3-pyrrolidinol
(R)-(−)-1-Methyl-3-pyrrolidinol (CAS: 104641-60-3; Formula: C5H11NO) is a chiral heterocyclic compound with a molecular weight of 101.15 g/mol. This valuable building block is primarily employed in asymmetric synthesis for the preparation of complex organic molecules. Its specific stereochemistry makes it a sought-after intermediate in the development of novel pharmaceuticals and biologically active compounds, contributing to advancements in medicinal chemistry.
- IUPAC
- (3R)-1-Methylpyrrolidin-3-ol,(R)-(−)-3-Hydroxy-N-methylpyrrolidine,(R)-N-Methyl-3-pyrrolidinol
- Synonyms
- (3R)-1-Methylpyrrolidin-3-ol(R)-(−)-3-Hydroxy-N-methylpyrrolidine(R)-N-Methyl-3-pyrrolidinol
Asymmetric Synthesis of Nucleoside Analogs
This chiral pyrrolidinol serves as a key reactant in the asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs. These compounds are investigated as potential DNA methyltransferase inhibitors for various therapeutic applications.
Preparation of Adenosine Receptor Antagonists
It is utilized in the preparation of diaryl acylaminopyrimidines. These derivatives have been explored for their potential as adenosine A2A antagonists, a class of compounds with therapeutic interest in neurological disorders.
Synthesis of Na+,K+-ATPase Inhibitors
The compound is employed in the synthesis of analogs of istaroxime. Istaroxime is a potent inhibitor of Na+,K+-ATPase, suggesting potential applications in cardiovascular medicine.
Development of Soft Anticholinergics
It plays a role in the synthesis of pharmacologically active stereoisomers of N-substituted soft anticholinergics, contributing to the development of new agents for managing conditions requiring anticholinergic activity.
| Molecular weight | 101.15 |
|---|---|
| Empirical formula | C5H11NO |
| Assay | 97% |
| Boiling point | 50-52 °C/1 mmHg(lit.) |
| Density | 0.921 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4640(lit.) |
| Optical activity | [α]20/D -7°, c = 1% in chloroform |
| Application | Reactant for:• Asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors1• Preparation of diaryl acylaminopyrimidines as adenosine A2A antagonists2• Synthesis of analogs of istaroxime, a potent inhibitor of Na+,K+-ATPase3• Synthesis of pharmacologically active stereoisomers of N-substituted soft anticholinergics4 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 70 °C / 158 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-1-Methyl-3-pyrrolidinol used for?
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(R)-(−)-1-Methyl-3-pyrrolidinol is primarily used as a reactant in asymmetric synthesis for the creation of complex chiral molecules, including pharmaceutical intermediates and biologically active compounds.
What is the CAS number and formula for (R)-(−)-1-Methyl-3-pyrrolidinol?
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The CAS number is 104641-60-3, and the empirical formula is C5H11NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(−)-1-Methyl-3-pyrrolidinol with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated in the product specifications.
What are the safety considerations when handling this chemical?
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This compound is classified with GHS07 and carries a Warning signal word. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, should be used, and handling should occur in a well-ventilated area or fume hood.
Does Tech Serve Solutions export this chemical?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including (R)-(−)-1-Methyl-3-pyrrolidinol.
How can I request a sample or quote for (R)-(−)-1-Methyl-3-pyrrolidinol?
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To request a sample or obtain a quote, please visit the product page on the Tech Serve Solutions website or contact our sales team directly.
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