(R)-(+)-1-Boc-2-pyrrolidinecarbonitrile
(R)-(+)-1-Boc-2-pyrrolidinecarbonitrile (CAS: 228244-20-0), with the molecular formula C10H16N2O2 and a molecular weight of 196.25 g/mol, is a valuable chiral building block. This compound serves as a key intermediate in asymmetric synthesis, particularly for the construction of complex heterocyclic molecules. Its defined stereochemistry makes it instrumental in developing enantiomerically pure pharmaceuticals and other fine chemicals, facilitating stereoselective reaction pathways.
Chiral Building Block in Asymmetric Synthesis
This compound is extensively used as a chiral synthon in asymmetric synthesis. Its pyrrolidine core and nitrile functionality offer versatile handles for stereocontrolled elaboration into more complex molecules.
Pharmaceutical Intermediate
Its enantiopure nature makes it a sought-after intermediate in the synthesis of pharmacologically active compounds. It facilitates the construction of drug candidates requiring specific stereochemical configurations for efficacy and safety.
Heterocyclic Chemistry
The compound is a valuable precursor for synthesizing various substituted pyrrolidines and other nitrogen-containing heterocycles. These structures are prevalent in medicinal chemistry and materials science.
| Molecular weight | 196.25 |
|---|---|
| Empirical formula | C10H16N2O2 |
| Assay | 97% |
| Optical activity | [α]20/D +105°, c = 1% in chloroform |
| Melting point | 32-36 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38-43 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-1-Boc-2-pyrrolidinecarbonitrile used for?
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(R)-(+)-1-Boc-2-pyrrolidinecarbonitrile is primarily used as a chiral building block in asymmetric synthesis and as an intermediate in the preparation of pharmaceuticals and other complex organic molecules.
What are the CAS number and formula for (R)-(+)-1-Boc-2-pyrrolidinecarbonitrile?
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The CAS number is 228244-20-0, and the molecular formula is C10H16N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(+)-1-Boc-2-pyrrolidinecarbonitrile with an assay of 97%. TSS does not represent this product as USP, BP, or EP grade.
How should (R)-(+)-1-Boc-2-pyrrolidinecarbonitrile be handled?
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Based on its GHS classification (Warning: H302-H315-H317-H319-H335), appropriate personal protective equipment including a dust mask (N95), eyeshields, face shields, and gloves should be used. Handle in a well-ventilated area. Avoid contact with skin, eyes, and clothing, and avoid breathing dust.
Is (R)-(+)-1-Boc-2-pyrrolidinecarbonitrile available for international export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals and laboratory reagents.
How can I request a sample or quote for (R)-(+)-1-Boc-2-pyrrolidinecarbonitrile?
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Please contact our sales department through the website or by phone to request a sample or a quotation for (R)-(+)-1-Boc-2-pyrrolidinecarbonitrile.
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