(R)-(−)-1-Benzyl-3-hydroxypiperidine
(R)-(−)-1-Benzyl-3-hydroxypiperidine (CAS 91599-81-4) is a chiral piperidine derivative with the molecular formula C12H17NO and a molecular weight of 191.27 g/mol. This enantiomerically pure compound serves as a valuable chiral building block in asymmetric synthesis and chemical research. Its specific stereochemistry makes it useful for the stereoselective construction of complex molecules, particularly in pharmaceutical and fine chemical development.
- IUPAC
- (R)-1-Benzyl-3-piperidinol

Chiral Building Block
Utilised in asymmetric synthesis for the creation of enantiomerically pure compounds. It provides a defined stereochemical centre for constructing complex molecular architectures.
Pharmaceutical Intermediate
Serves as a key intermediate in the synthesis of pharmaceutically active ingredients. Its piperidine ring and chiral hydroxyl group are common structural motifs in drug discovery.
Research and Development
Employed in academic and industrial research laboratories for exploring new synthetic routes and developing novel chemical entities. It aids in the investigation of stereoselective reactions.
| Molecular weight | 191.27 |
|---|---|
| Empirical formula | C12H17NO |
| Assay | 97% |
| Boiling point | 275 °C(lit.) |
| Density | 1.07 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.547(lit.) |
| Optical activity | [α]24/D −12°, c = 1 in methanol |

Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-1-Benzyl-3-hydroxypiperidine used for?
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This compound is primarily used as a chiral building block in asymmetric synthesis and as an intermediate in the development of pharmaceutical agents and other fine chemicals. It is valuable for stereoselective synthesis and research applications.
What is the CAS number and formula for (R)-(−)-1-Benzyl-3-hydroxypiperidine?
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The CAS number is 91599-81-4, and the molecular formula is C12H17NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(−)-1-Benzyl-3-hydroxypiperidine with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for this chemical?
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(R)-(−)-1-Benzyl-3-hydroxypiperidine is classified as Dangerous. It is toxic if swallowed (H301), causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, is essential during handling. Always consult the Safety Data Sheet (SDS) before use.
How is this product packed and exported by TSS?
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Tech Serve Solutions, a global supplier and exporter, packs and ships (R)-(−)-1-Benzyl-3-hydroxypiperidine in compliance with international regulations for hazardous materials (UN 2810, 6.1, PGIII). We cater to global research and industrial clients.
How can I request a sample or quote for (R)-(−)-1-Benzyl-3-hydroxypiperidine?
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Please contact our sales team via our website or direct email to request a sample or obtain a quotation for (R)-(−)-1-Benzyl-3-hydroxypiperidine. We aim to respond promptly to all inquiries.
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