Propionyl chloride
Propionyl chloride (CAS: 79-03-8), with the linear formula CH₃CH₂COCl and a molecular weight of 92.52 g/mol, is a reactive acyl halide. It is a colourless to yellow liquid with a pungent odour. Propionyl chloride serves as a key intermediate in organic synthesis, particularly for introducing the propionyl group into various molecules. It is widely employed in the production of pharmaceuticals, agrochemicals, and specialty chemicals.
Pharmaceutical Intermediate
Propionyl chloride is used in the synthesis of active pharmaceutical ingredients (APIs) and drug intermediates. Its reactivity allows for the efficient introduction of the propionyl moiety, crucial for the biological activity of certain compounds.
Agrochemical Synthesis
In the agrochemical sector, it functions as a building block for creating various pesticides, herbicides, and fungicides. The propionyl group can be incorporated to modify the efficacy and properties of these agricultural products.
Organic Synthesis Reagent
As a versatile organic building block, propionyl chloride is employed in acylation reactions to produce esters, amides, and ketones. It is valuable for creating complex organic molecules in research and industrial settings.
Dye and Pigment Manufacturing
It can be utilised in the synthesis of certain dyes and pigments, where the propionyl group contributes to the chromophoric system or modifies the solubility and application properties of the colourant.
| Molecular weight | 92.52 |
|---|---|
| Linear formula | CH3CH2COCl |
| Assay | 98% |
| Boiling point | 77-79 °C(lit.) |
| Density | 1.059 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.404(lit.) |
| Vapour density | 3.2 (vs air) |
| Melting point | −94 °C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 6 °C / 42.8 °F |
| Transport (UN / ADR) | UN 1815 8(3) / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-34 |
| Safety statements (S) | 9-16-26-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Propionyl chloride used for?
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Propionyl chloride is primarily used as an intermediate in organic synthesis for producing pharmaceuticals, agrochemicals, dyes, and other specialty chemicals by introducing the propionyl group into molecules.
What is the CAS number and formula for Propionyl chloride?
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The CAS number for Propionyl chloride is 79-03-8, and its linear formula is CH₃CH₂COCl.
What grade and purity does Tech Serve Solutions supply for Propionyl chloride?
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Tech Serve Solutions supplies Propionyl chloride with an assay of 98%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
How should Propionyl chloride be handled safely?
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Propionyl chloride is highly flammable and corrosive, causing severe skin burns and eye damage. It reacts violently with water. Handle with extreme care using appropriate personal protective equipment, including gloves, goggles, face shields, and respirators, in a well-ventilated area away from ignition sources and water.
How is Propionyl chloride packed and exported?
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Propionyl chloride is packed and shipped according to international regulations for hazardous materials, including UN 1815 classification. We ensure secure packaging for export.
How can I request a quote or sample of Propionyl chloride?
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To request a quote or sample, please contact our sales team through the website or call us directly. Provide the product name and CAS number (79-03-8) for prompt service.
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