Propionic anhydride
Propionic anhydride (CAS 123-62-6), with the linear formula (CH3CH2CO)2O and a molecular weight of 130.14 g/mol, is a carboxylic acid anhydride. This colourless liquid serves as an important reagent in organic synthesis, particularly for acylation reactions. It is widely used in the preparation of various propionyl derivatives across chemical research and industrial applications.
- IUPAC
- Propanoic anhydride
- Synonyms
- Propanoic anhydride
Acylation Reagent
Propionic anhydride is employed as a propionylating agent to introduce the propionyl group (CH3CH2CO-) onto alcohols, amines, and other nucleophiles. This is crucial in the synthesis of esters, amides, and other organic compounds.
Pharmaceutical Intermediate Synthesis
It acts as a key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and their precursors. Its reactivity allows for the efficient modification of complex molecules.
Preparation of Derivatives
As demonstrated in research, propionic anhydride is used in the preparation of specific derivatives, such as the α- and β-1-propionyl derivatives of glucopyranose tetra-acetate, highlighting its role in carbohydrate chemistry.
| Molecular weight | 130.14 |
|---|---|
| Linear formula | (CH3CH2CO)2O |
| Assay | ≥96.0% (NT) |
| Boiling point | 167 °C(lit.) |
| Density | 1.010 g/mL at 20 °C1.015 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.404(lit.)n20/D 1.404 |
| Vapour pressure | 10 mmHg (57.7 °C) |
| Melting point | −43 °C(lit.) |
| Vapour density | 4.5 (vs air) |
| Autoignition temp | 545 °F |
| Application | Propionic anhydride (propanoic anhydride) was used in the preparation of α- and β-1-propionyl derivatives of glucopyranose tetra-acetate1. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 74 °C / 165.2 °F |
| Transport (UN / ADR) | UN 2496 8 / PGIII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Expl Lim | 11.9 % |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Propionic anhydride used for?
+
Propionic anhydride is primarily used as an acylation reagent in organic synthesis for introducing propionyl groups, and as an intermediate in the synthesis of pharmaceuticals and other complex organic molecules.
What are the CAS number and formula for Propionic anhydride?
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The CAS number for Propionic anhydride is 123-62-6, and its linear formula is (CH3CH2CO)2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Propionic anhydride with an assay of ≥96.0% (NT). We do not represent this product as USP, BP, or EP grade unless explicitly stated in the product specifications.
How should Propionic anhydride be handled safely?
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Propionic anhydride is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Handling requires full protective equipment, including faceshields, gloves, goggles, and appropriate respiratory protection. Strict adherence to safety protocols is essential.
How is Propionic anhydride packed and shipped?
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Propionic anhydride is shipped as UN 2496, Class 8, Packing Group III, indicating it is a corrosive material. Packaging adheres to international regulations for the safe transport of hazardous chemicals.
How can I request a sample or quote for Propionic anhydride?
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To request a sample or obtain a quote for Propionic anhydride, please contact our sales team through the website or by phone, providing your specific requirements.
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