Propargyl-N-hydroxysuccinimidyl ester
Propargyl-N-hydroxysuccinimidyl ester (CAS: 1174157-65-3, Formula: C10H11NO5, MW: 225.20) is a versatile amine-reactive reagent. It enables the introduction of a terminal alkyne group onto peptides, antibodies, and amine-functionalised surfaces. This functionalised alkyne is readily available for subsequent conjugation reactions, notably copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry, to form stable triazole linkages. It is supplied for research and chemical synthesis applications.
- IUPAC
- 2,5-Dioxopyrrolidin-1-yl 3-(prop-2-ynyloxy)propanoate,3-(2-Propyn-1-yloxy)propanoic acid 2,5-dioxo-1-pyrrolidinyl ester,Alkyne-NHS ester,Propargyl-succinimidyl-ester
- Synonyms
- 2,5-Dioxopyrrolidin-1-yl 3-(prop-2-ynyloxy)propanoate3-(2-Propyn-1-yloxy)propanoic acid 2,5-dioxo-1-pyrrolidinyl esterAlkyne-NHS esterPropargyl-succinimidyl-ester
Bioconjugation via Click Chemistry
Propargyl-NHS ester facilitates the covalent attachment of a terminal alkyne to primary amines found on biomolecules like proteins and peptides. This alkyne handle is then primed for highly efficient and specific click reactions with azide-modified molecules, leading to stable triazole conjugates.
Surface Functionalisation
This reagent can be used to modify amine-coated surfaces or materials. The immobilised alkyne groups then serve as anchor points for further functionalisation using click chemistry, enabling the creation of tailored surfaces for biosensing or material science applications.
Peptide and Protein Labelling
The amine reactivity of the NHS ester allows for selective labelling of lysine residues or N-termini in peptides and proteins. The incorporated propargyl group enables subsequent conjugation to other molecules, such as fluorescent dyes or affinity tags, equipped with an azide moiety.
| Molecular weight | 225.20 |
|---|---|
| Empirical formula | C10H11NO5 |
| Storage temperature | −20°C |
| Application | Propargyl-NHS ester is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc, with a terminal alkyne. The alkyne can be reacted with an azide containing compound or biomolecule via copper catalyzed azide-alkyne click chemistry to yield a stable triazole linkage. |
| Melting point | 36-41 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Propargyl-N-hydroxysuccinimidyl ester used for?
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Propargyl-N-hydroxysuccinimidyl ester is used to introduce a terminal alkyne group onto amine-containing molecules and surfaces. This alkyne moiety is then available for conjugation reactions, particularly copper-catalyzed azide-alkyne click chemistry (CuAAC), to form stable triazole linkages.
What is the CAS number and formula for Propargyl-N-hydroxysuccinimidyl ester?
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The CAS number is 1174157-65-3 and the empirical formula is C10H11NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and chemical synthesis. The specific assay and purity details are available on the product's Certificate of Analysis. We do not represent this product as USP, BP, EP, or pharmacopoeia grade unless explicitly stated.
How should Propargyl-N-hydroxysuccinimidyl ester be handled and stored?
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The safety data sheet (SDS) for Propargyl-N-hydroxysuccinimidyl ester should be consulted for detailed handling precautions. It is typically stored at -20°C to maintain stability. Please refer to the SDS for specific hazards and personal protective equipment recommendations.
Is Propargyl-N-hydroxysuccinimidyl ester a controlled substance?
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Based on the provided data, there is no indication that Propargyl-N-hydroxysuccinimidyl ester is a controlled substance.
How are your chemicals packed and shipped?
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Tech Serve Solutions packs and ships chemicals according to international regulations for hazardous materials, ensuring safe and compliant transport for global export. Specific packaging details may vary depending on the quantity and nature of the chemical.
How can I request a sample or quote for Propargyl-N-hydroxysuccinimidyl ester?
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To request a sample or a quote, please use the contact form on our website or email our sales department, providing the product name and CAS number (1174157-65-3).
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