Propargyl chloroformate
Propargyl chloroformate (CAS: 35718-08-2) is a reactive organic compound with the linear formula HC≡CCH₂OCOCl and a molecular weight of 118.52 g/mol. It functions as a versatile intermediate in organic synthesis, particularly for introducing the propargyloxycarbonyl group. This chemical is an acid halide and carbonyl compound, valuable for various chemical transformations in research and industrial settings.
Protecting Group Chemistry
Propargyl chloroformate serves as an effective reagent for the introduction of the propargyloxycarbonyl (Proc) protecting group onto alcohols and amines. This protection strategy is widely employed in the synthesis of complex organic molecules.
Organic Synthesis Intermediate
As a building block, it is utilised in the construction of diverse organic structures. Its reactivity as an acid halide allows for facile derivatisation and incorporation into larger molecular frameworks.
Pharmaceutical and Agrochemical Research
The compound finds application in research and development within the pharmaceutical and agrochemical sectors, contributing to the synthesis of novel active ingredients and advanced intermediates.
| Molecular weight | 118.52 |
|---|---|
| Linear formula | HC≡CCH2OCOCl |
| Assay | 96% |
| Boiling point | 118-122 °C(lit.) |
| Density | 1.215 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.435(lit.) |
| Vapour pressure | 0.65 psi (20 °C) |
| Storage temperature | 2-8°C |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H311Toxic in contact with skin
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 30 °C / 86 °F |
| Transport (UN / ADR) | UN 3390 6.1/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 10-22-23/24-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Propargyl chloroformate primarily used for?
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Propargyl chloroformate is primarily used as an intermediate in organic synthesis, particularly for introducing the propargyloxycarbonyl (Proc) protecting group onto alcohols and amines.
What is the CAS number and formula for Propargyl chloroformate?
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The CAS number is 35718-08-2, and its linear formula is HC≡CCH₂OCOCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Propargyl chloroformate with an assay of 96%. This is a technical/research grade chemical and TSS does not represent it as USP, BP, or EP grade.
How should Propargyl chloroformate be handled safely?
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Propargyl chloroformate is a Danger substance, flammable, harmful if swallowed, toxic in contact with skin and if inhaled, and causes severe skin burns and eye damage. Handle with extreme caution using appropriate personal protective equipment including face shields, full-face respirators, gloves, and chemical-resistant goggles. Ensure adequate ventilation.
Is Propargyl chloroformate available for export?
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Yes, Tech Serve Solutions, as a specialist global supplier and exporter, can ship and export Propargyl chloroformate worldwide, adhering to all relevant regulations.
How can I request a quote or sample for Propargyl chloroformate?
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To request a quote or a sample of Propargyl chloroformate, please use the contact form on our website or call our sales department directly.
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