Pepstatin A

CAS 26305-03-3C34H63N5O9Biochemicals & Reagents

Pepstatin A (CAS: 26305-03-3), with the molecular formula C34H63N5O9 and a molecular weight of 685.89 g/mol, is a highly effective inhibitor of aspartic proteases. Derived from microbial sources, this peptide acts as a potent biochemical tool. It is primarily utilised in research settings to inhibit the degradation of autophagic cargo within autophagosomes, often in conjunction with other inhibitors like E64-d and Leupeptin A.

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Pepstatin A (C34H63N5O9) — chemical structure, CAS 26305-03-3; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyCore BioreagentsEnzyme InhibitorsEnzymesInhibitorsand SubstratesMiscellaneous PeptidesMolecular Biology

01 /Applications

Autophagy Inhibition

Pepstatin A is employed to block the activity of aspartic proteases, thereby preventing the breakdown of autophagic cargo. This is crucial for studying autophagosome dynamics and contents in cellular research.

Enzyme Inhibition Studies

As a specific inhibitor of aspartic proteases, Pepstatin A is valuable for researchers investigating enzyme mechanisms and pathways involving these enzymes in various biological systems.

Biochemical Research

Its role in preserving protein integrity within cellular compartments makes Pepstatin A a useful reagent in molecular biology and cell biology research, particularly when analysing protein degradation pathways.

02 /Properties

Molecular weight	685.89
Empirical formula	C34H63N5O9
Assay	≥75% (HPLC)
Storage temperature	2-8°C
Application	Can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. For this application, the working concentration is typically between 1-10 μM.
Biological source	microbial
Melting point	233 °C (dec.)(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	2

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

26305-03-3

MDL number

MFCD00060740

PubChem substance

24898519

Beilstein registry

2201362

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Pepstatin A used for?

Pepstatin A is used to inhibit the degradation of autophagic cargo inside autophagosomes, often in conjunction with other inhibitors like E64-d and Leupeptin A. It is also a key reagent for studying aspartic protease activity in biochemical and cell biology research.

What is the CAS number and formula for Pepstatin A?

The CAS number for Pepstatin A is 26305-03-3, and its empirical formula is C34H63N5O9.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Pepstatin A with an assay of ≥75% (HPLC). This product is intended for research purposes and is not represented as USP, BP, or EP grade.

How should Pepstatin A be handled and stored?

Handle Pepstatin A with appropriate personal protective equipment, including eyeshields, gloves, and a respirator filter (type N95 or P1). Store the product at 2-8°C to maintain its integrity.

Is Pepstatin A a controlled substance?

Based on the provided data, Pepstatin A is not listed as a controlled substance.

How are Pepstatin A products shipped?

Pepstatin A is typically stored at 2-8°C. TSS exports fine chemicals globally, adhering to all necessary shipping and handling regulations for chemical products.