2,6-Difluorobenzyl bromide
2,6-Difluorobenzyl bromide (CAS: 85118-00-9) is a fluorinated organic building block with the linear formula F₂C₆H₃CH₂Br and a molecular weight of 207.02 g/mol. This aryl halide serves as a valuable reagent in organic synthesis, particularly for alkylation reactions. It is utilised in the preparation of diverse chemical entities, including pharmaceutical intermediates and novel compounds with potential biological activities. Its unique structure makes it a key component in constructing complex molecules.
- IUPAC
- α-Bromo-2,6-difluorotoluene
- Synonyms
- F2C6H3CH2Brα-Bromo-2,6-difluorotoluene
Alkylation Reactions
2,6-Difluorobenzyl bromide is employed as an alkylating agent in the synthesis of various heterocyclic compounds. It has been specifically used in the alkylation of quinazoline-2-thioxo-4-one derivatives, forming new chemical scaffolds.
Synthesis of Triazine Derivatives
This compound has found application in the preparation of 1,3,5-triazine-2,4,6-triones. These reactions contribute to the development of novel organic structures with potential industrial applications.
Antiviral Research
In medicinal chemistry research, 2,6-Difluorobenzyl bromide has been utilised in the preparation of compounds investigated for their antiviral properties. It has been part of syntheses targeting inhibitors of viruses like the bovine viral diarrhea virus.
| Molecular weight | 207.02 |
|---|---|
| Linear formula | F2C6H3CH2Br |
| Assay | 97% |
| Application | 2,6-Difluorobenzyl bromide has been used:• as reagent in alkylation of the quinazoline-2-thioxo-4-one1• in the synthesis of 1,3,5-triazine-2,4,6-triones2• in the preparation of new classes of inhibitors of bovine viral diarrhea virus (as a surrogate virus for hepatitis C virus)3 |
| Melting point | 52-55 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Difluorobenzyl bromide used for?
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2,6-Difluorobenzyl bromide is primarily used as a reagent in organic synthesis for alkylation reactions, in the preparation of 1,3,5-triazine-2,4,6-triones, and in research for potential antiviral agents.
What are the CAS number and chemical formula for 2,6-Difluorobenzyl bromide?
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The CAS number is 85118-00-9, and the linear chemical formula is F₂C₆H₃CH₂Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,6-Difluorobenzyl bromide with an assay of 97%. This product is typically supplied for research and development purposes and is not represented as USP, BP, or EP grade.
How should 2,6-Difluorobenzyl bromide be handled safely?
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2,6-Difluorobenzyl bromide is a corrosive substance (H314). Handling requires appropriate personal protective equipment, including eyeshields, face shields, and chemical-resistant gloves. Ensure adequate ventilation and use respiratory protection if necessary. Consult the Safety Data Sheet for detailed handling procedures.
How is 2,6-Difluorobenzyl bromide packed, shipped, and exported?
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2,6-Difluorobenzyl bromide is packaged according to stringent safety and regulatory standards for the transport of hazardous materials. Tech Serve Solutions, as an experienced global supplier, ensures compliant packing, shipping, and export procedures.
How can I request a sample or quote for 2,6-Difluorobenzyl bromide?
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To request a sample or a quote, please visit the Tech Serve Solutions website or contact our sales department directly with your specific requirements.
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