2,6-Difluorobenzoic acid
2,6-Difluorobenzoic acid (CAS: 385-00-2), a fluorinated aromatic carboxylic acid with the molecular formula C7H4F2O2 and a molecular weight of 158.10 g/mol, serves as a valuable building block in organic synthesis. Its structure, featuring two fluorine atoms ortho to the carboxyl group, imparts unique reactivity, making it useful in the preparation of complex organic molecules and pharmaceutical intermediates. Available at 98% purity, it is a key reagent for chemical research and development.
- Synonyms
- F2C6H3CO2H
Synthesis of Pharmaceutical Intermediates
2,6-Difluorobenzoic acid is employed in the synthesis of advanced intermediates for pharmaceuticals. For example, it has been utilized in the creation of complex heterocyclic compounds like 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide, which may have applications in drug discovery.
Preparation of Organic Esters
The compound is a precursor for the synthesis of various organic esters. A notable example is its use in preparing methyl 2,6-difluorobenzoate, an ester that can further be employed in more elaborate synthetic pathways within organic chemistry research.
Fluorinated Building Block
As a difluorinated aromatic compound, 2,6-Difluorobenzoic acid functions as a crucial building block in constructing fluorinated organic molecules. These molecules are of significant interest in agrochemicals and materials science due to the unique properties conferred by fluorine atoms.
| Molecular weight | 158.10 |
|---|---|
| Linear formula | F2C6H3CO2H |
| Assay | 98% |
| Application | 2,6-Difluorobenzoic acid has been used in the synthesis of 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide and methyl 2,6-difluorobenzoate1. |
| Melting point | 157-161 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Difluorobenzoic acid used for?
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2,6-Difluorobenzoic acid is primarily used as a building block in organic synthesis for the preparation of pharmaceutical intermediates and other complex fluorinated organic molecules. It has been used in the synthesis of compounds such as 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide and methyl 2,6-difluorobenzoate.
What is the CAS number and molecular formula for 2,6-Difluorobenzoic acid?
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The CAS number for 2,6-Difluorobenzoic acid is 385-00-2, and its linear formula is F2C6H3CO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,6-Difluorobenzoic acid with a purity of 98%. This product is intended for research and chemical synthesis purposes. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
What are the safety considerations for handling 2,6-Difluorobenzoic acid?
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2,6-Difluorobenzoic acid is classified as a warning substance (GHS07). It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including dust masks (type N95), eyeshields, and gloves, should be worn. Handle in a well-ventilated area.
How is 2,6-Difluorobenzoic acid typically packed and exported?
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2,6-Difluorobenzoic acid is carefully packed to ensure safe handling and transit. As a global supplier, Tech Serve Solutions has extensive experience in exporting chemicals worldwide, adhering to all relevant international shipping regulations.
How can I request a sample or obtain a quote for 2,6-Difluorobenzoic acid?
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To request a sample or obtain a quotation for 2,6-Difluorobenzoic acid, please contact the Tech Serve Solutions sales team through our website or by phone. Provide your details and the quantity required.
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