2,6-Difluorobenzoyl chloride
2,6-Difluorobenzoyl chloride (CAS: 18063-02-0), with the linear formula F2C6H3COCl and a molecular weight of 176.55 g/mol, is a key aryl fluorinated building block. This acid halide is vital in organic synthesis, particularly for introducing the 2,6-difluorobenzoyl moiety into various molecules. Its reactivity makes it a valuable intermediate in the development of pharmaceuticals and agrochemicals, facilitating complex molecular constructions.
- Synonyms
- F2C6H3COCl
Synthesis of Benzoxazinones
2,6-Difluorobenzoyl chloride is employed in the preparation of novel 2-aryl substituted 4<i>H</i>-3,1-benzoxazin-4-ones, contributing to the development of new heterocyclic compounds.
Imidazo[1,2-a]pyridine Synthesis
This compound facilitates the regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2-a]pyridines, a class of compounds with potential biological activity.
Friedel-Crafts Acylation
It participates in Friedel-Crafts acylation reactions with various aromatic substrates, including toluene, anisol, and thioanisol, enabling the formation of new carbon-carbon bonds.
| Molecular weight | 176.55 |
|---|---|
| Linear formula | F2C6H3COCl |
| Assay | 99% |
| Boiling point | 72-77 °C/13 mmHg(lit.) |
| Density | 1.404 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.501(lit.) |
| Application | 2,6-Difluorobenzoyl chloride has been used in:• the preparation of series of novel 2-aryl substituted 4H-3,1-benzoxazin-4-ones1• regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2-a]pyridine2• Friedel-Crafts acylation reaction of toluene, anisol, thioanisol, 4-phenoxyacetophenone and N,N-diacetyl-4-phenoxyaniline3 |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 46 °C / 114.8 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Difluorobenzoyl chloride used for?
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2,6-Difluorobenzoyl chloride is used as a building block in organic synthesis, notably in the preparation of benzoxazinones, imidazo[1,2-a]pyridines, and in Friedel-Crafts acylation reactions.
What is the CAS number and formula for 2,6-Difluorobenzoyl chloride?
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The CAS number is 18063-02-0, and the linear formula is F2C6H3COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,6-Difluorobenzoyl chloride with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should 2,6-Difluorobenzoyl chloride be handled?
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2,6-Difluorobenzoyl chloride is a corrosive and flammable liquid. Handle with extreme care, using appropriate personal protective equipment including gloves, goggles, face shield, and a suitable respirator. Ensure adequate ventilation.
Is 2,6-Difluorobenzoyl chloride shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,6-Difluorobenzoyl chloride.
How can I request a sample or quote for 2,6-Difluorobenzoyl chloride?
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Please contact our sales team directly via phone or email to request a sample or a quote for 2,6-Difluorobenzoyl chloride.
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