Nisoldipine

CAS 63675-72-9C20H24N2O6Cell Biology

Nisoldipine (CAS 63675-72-9, C20H24N2O6) is a dihydropyridine calcium channel modulator with a molecular weight of 388.41 g/mol. Supplied as a yellow powder, it is primarily utilised in research applications as an inhibitor and activator of voltage-gated ion channels. Its selective action on L-type calcium channels makes it a valuable tool in cell biology and neuroscience research for investigating cellular signaling pathways.

IUPAC: (±)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate,1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester,Sular
Synonyms: Sular(±)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester

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Nisoldipine (C20H24N2O6) — chemical structure, CAS 63675-72-9; Life Science, fine chemical supplied by Tech Serve Solutions

BayerBioactive Small MoleculesCalcium Channel ModulatorsCell BiologyInhibitors and ActivatorsIon ChannelsShionogi

01 /Applications

Calcium Channel Modulation

Nisoldipine functions as a calcium channel modulator, specifically targeting voltage-gated L-type calcium channels. This action is crucial for studying cellular electrophysiology and signalling in various biological systems.

Neuroscience Research Tool

As a selective inhibitor and activator of ion channels, Nisoldipine is employed in neuroscience to investigate the role of calcium influx in neuronal function and synaptic transmission.

Cell Biology Studies

The compound aids in cell biology research by providing a means to modulate calcium homeostasis, which is vital for numerous cellular processes including proliferation, differentiation, and apoptosis.

02 /Properties

Molecular weight	388.41
Empirical formula	C20H24N2O6
Assay	≥98% (HPLC)
Form	powder
Colour	yellow
Solubility	DMSO: >10 mg/mL
Storage temperature	room temp

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection

Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	20/21/22
Safety statements (S)	36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

63675-72-9

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Nisoldipine used for?

Nisoldipine is used in research as a calcium channel modulator and an inhibitor/activator of voltage-gated ion channels, aiding studies in cell biology and neuroscience.

What are the CAS number and formula for Nisoldipine?

The CAS number for Nisoldipine is 63675-72-9, and its molecular formula is C20H24N2O6.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Nisoldipine with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.

What are the safety considerations when handling Nisoldipine?

Nisoldipine is classified with a GHS07 symbol and the signal word Warning. It is harmful if swallowed (H302) and harmful in contact with skin (H312). Always handle with appropriate personal protective equipment (P280) in a well-ventilated area.

How is Nisoldipine packed and exported?

Nisoldipine is typically supplied as a yellow powder, stored at room temperature. TSS exports chemicals globally, adhering to all relevant shipping and regulatory requirements.