Neomycin trisulfate salt hydrate

CAS 1405-10-3C23H46N6O13 · 3H2SO4 · xH2OBiochemicals & Reagents

Neomycin trisulfate salt hydrate (CAS: 1405-10-3) is an aminoglycoside antibiotic derived from *Streptomyces*. It is supplied by Tech Serve Solutions with a minimum of 85% neomycin B. This compound is primarily recognised for its role as a selection agent in prokaryotic cell culture, aiding in genetic manipulation studies. It also finds use in research for investigating antibiotic side effects and cellular signalling pathways.

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Neomycin trisulfate salt hydrate (C23H46N6O13 · 3H2SO4 · xH2O) — chemical structure, CAS 1405-10-3; Life Science, fine chemical supplied by Tech Serve Solutions

AminoglycosidesAntibacterialAntibioticsAntibiotics A to ZAntibiotics N-SAntibiotics by ApplicationBiochemicals and ReagentsChemical Structure ClassGenetic Marker SelectionMechanism of Action

01 /Applications

Antibiotic Selection in Molecular Biology

Neomycin trisulfate hydrate serves as an effective selection agent for prokaryotic cells that have been successfully transformed with the neo selectable marker gene. This allows researchers to identify and isolate successfully engineered organisms.

Research into Antibiotic Ototoxicity

This compound is utilised in laboratory settings to study the ototoxic (ear-damaging) side effects associated with aminoglycoside antibiotics. Such research is crucial for understanding and mitigating potential adverse reactions.

Investigating Cellular Signalling

Neomycin trisulfate hydrate is employed to probe specific cellular processes, such as platelet-derived growth factor responses in fibroblasts and the extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins.

Cell Culture Applications

Recommended for use in cell culture media at a concentration of 50 mg/L, this compound supports various experimental protocols by providing a selective pressure or acting as a research tool.

02 /Properties

Molecular weight	908.88 (anhydrous basis)
Empirical formula	C23H46N6O13 · 3H2SO4 · xH2O
Solubility	H2O: soluble50 mg/mL (Stock solutions should be filter sterilized and stored at 2-8 °C. Stable at 37 °C for 5 days.)
Application	Neomycin Trisulfate is produced by Streptomyces containing a minimum of 85% neomycin B. It has been used as a selection agent for prokaryotic cells transformed using the neo selectable marker gene, and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins. It is recommended for use in cell culture applications at 50 mg/L.
Suitability	meets USP testing specifications

03 /Safety & handling

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms if inhaled

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P280Wear protective gloves, clothing and eye/face protection
P342

Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	42/43
Safety statements (S)	22-36/37-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1405-10-3

05 /Additional specifications

Market Segment	Agriculture
Potency	≥600 μg neomycin per mg (Dried basis)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Neomycin trisulfate salt hydrate used for?

Neomycin trisulfate salt hydrate is primarily used as a selection agent for prokaryotic cells transformed with the neo selectable marker gene. It is also used in research to study ototoxic side effects of antibiotics and investigate cellular signalling pathways, with recommended use in cell culture at 50 mg/L.

What is the CAS number and formula for Neomycin trisulfate salt hydrate?

The CAS number is 1405-10-3 and the empirical formula is C23H46N6O13 · 3H2SO4 · xH2O.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Neomycin trisulfate salt hydrate meeting USP testing specifications, with a potency of ≥600 μg neomycin per mg on a dried basis and a minimum of 85% neomycin B. TSS does not represent this product as pharmacopoeia grade beyond stated specifications.

What are the safety considerations for handling Neomycin trisulfate salt hydrate?

Neomycin trisulfate salt hydrate is classified with GHS08 symbol and a Danger signal word, with hazard statements H317 (May cause an allergic skin reaction) and H334 (May cause allergy or asthma symptoms or breathing difficulties if inhaled). Handle with appropriate personal protective equipment, ensuring good ventilation and avoiding dust inhalation.

Is Neomycin trisulfate salt hydrate available for export?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Neomycin trisulfate salt hydrate. Please contact us for export inquiries.

How can I request a sample or quote for Neomycin trisulfate salt hydrate?

To request a sample or quote, please contact our sales team through the website or by phone. Provide the product name, CAS number (1405-10-3), and desired quantity.