Neohesperidin dihydrochalcone
Neohesperidin dihydrochalcone (CAS: 20702-77-6; C28H36O15) is a high-intensity sweetener derived from citrus. With a molecular weight of 612.58 g/mol, this disaccharide exhibits a sweetness approximately 1500 times that of sucrose. It finds application as a flavour enhancer and has been investigated for its potential therapeutic uses in managing inflammatory conditions related to reactive oxygen species.
- IUPAC
- 1-(4-((2-O-[6-Deoxy-α-L-mannopyranosyl]-β-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone

Food and Beverage Sweetener
Neohesperidin dihydrochalcone serves as a potent artificial sweetener, imparting intense sweetness with a clean taste profile. It is frequently used in a wide array of food and beverage products to reduce sugar content.
Pharmaceutical Research
Due to its properties, this compound has been utilised in scientific studies. Its potential as a therapeutic agent for treating reactive oxygen species-related inflammatory diseases is an area of ongoing research.
Analytical Standards
It can be employed as an analytical standard in studies assessing the levels of high-intensity sweeteners in various food matrices, aiding in quality control and research.
| Molecular weight | 612.58 |
|---|---|
| Empirical formula | C28H36O15 |
| Assay | ≥95% (HPLC) |
| Storage temperature | −20°C |
| Application | Neohesperidin dihydrochalcone has been used in a study to assess levels of nine high-intensity sweeteners in various foods. 1 It can be used as a therapeutic agent on reactive oxygen species-related inflammatory disease. 2 |
| Melting point | 156-158 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Sweetness | 1500 × sucrose |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Neohesperidin dihydrochalcone used for?
+
Neohesperidin dihydrochalcone is primarily used as a high-intensity sweetener in food and beverages, and it has been investigated for its potential therapeutic applications in inflammatory conditions.
What is the CAS number and formula for Neohesperidin dihydrochalcone?
+
The CAS number for Neohesperidin dihydrochalcone is 20702-77-6, and its empirical formula (Hill notation) is C28H36O15.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Neohesperidin dihydrochalcone with an assay of ≥95% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Neohesperidin dihydrochalcone be handled and stored?
+
Handle with appropriate personal protective equipment, including eyeshields and gloves, and a suitable respirator filter (type N95 or P1). It should be stored at −20°C.
How can I request a sample or quote for Neohesperidin dihydrochalcone?
+
To request a sample or a quotation, please contact our sales department through the TSS website or by direct inquiry.
Is Neohesperidin dihydrochalcone exported by TSS?
+
Yes, Tech Serve Solutions is a global supplier and exporter of Neohesperidin dihydrochalcone.
▶ Related products
![(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (C8H13N3O4) — chemical structure, CAS 138472-01-2; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F138472-01-2.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
C8H13N3O4
Biochemicals & Reagents![(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (C14H18N4O4) — chemical structure, CAS 162626-99-5; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F162626-99-5.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
C14H18N4O4
Biochemicals & Reagents
(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Biochemicals & Reagents

(±)-2-(p-Methoxyphenoxy)propionic acid
C10H12O4
Biochemicals & Reagents
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
C10H13NO2·HBr
Biochemicals & Reagents
(±)-2-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxyoctanoic acid
C8H16O3
Biochemicals & Reagents▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis