Nα-p-Tosyl-L-arginine methyl ester hydrochloride
Nα-p-Tosyl-L-arginine methyl ester hydrochloride (CAS: 1784-03-8) is a modified amino acid derivative with a molecular weight of 378.87 g/mol. It is primarily utilised as a chromogenic substrate in biochemical research and enzyme assays. This compound is a valuable tool for studying serine proteases, such as trypsin and thrombin, due to its specific cleavage properties. Its application extends to enzyme kinetics and inhibitor screening in pharmaceutical research.
- IUPAC
- TAME hydrochloride
- Synonyms
- TAME hydrochlorideN-Tosyl-L-arginine methyl ester hydrochloride
Enzyme Substrate
Nα-p-Tosyl-L-arginine methyl ester hydrochloride is widely employed as a chromogenic substrate for assaying the activity of serine proteases, including trypsin-like enzymes. Its hydrolysis by specific enzymes releases a detectable product, facilitating kinetic studies and enzyme characterisation.
Biochemical Research
In biochemical research, this compound serves as a tool for investigating protease function and developing enzyme inhibitors. Its well-defined cleavage site allows for precise measurement of enzyme activity in various biological contexts.
Enzyme Kinetics and Inhibitor Screening
It is instrumental in determining kinetic parameters of proteases and in high-throughput screening for potential drug candidates that inhibit enzyme activity. The reliable performance of TAME hydrochloride aids in the discovery of novel therapeutic agents.
| Molecular weight | 378.87 |
|---|---|
| Linear formula | H2NC(=NH)NH(CH2)3CH(NHSO2C6H4CH3)CO2CH3 · HCl |
| Storage temperature | −20°C |
| Melting point | 145-147(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nα-p-Tosyl-L-arginine methyl ester hydrochloride used for?
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Nα-p-Tosyl-L-arginine methyl ester hydrochloride (CAS: 1784-03-8) is used as a chromogenic substrate for the assay of serine proteases, particularly trypsin-like enzymes, in biochemical research and enzyme kinetics studies.
What is the CAS number and molecular formula for Nα-p-Tosyl-L-arginine methyl ester hydrochloride?
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The CAS number is 1784-03-8. The linear formula is H₂NC(=NH)NH(CH₂)₃CH(NHSO₂C₆H₄CH₃)CO₂CH₃ · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and laboratory use. We do not represent it as USP, BP, EP, or pharmacopoeia grade. Please refer to the Certificate of Analysis for specific purity details.
How should Nα-p-Tosyl-L-arginine methyl ester hydrochloride be handled and stored?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter may be necessary. Store at -20°C. Refer to the Safety Data Sheet (SDS) for comprehensive safety and handling information.
Is Nα-p-Tosyl-L-arginine methyl ester hydrochloride shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Nα-p-Tosyl-L-arginine methyl ester hydrochloride. We comply with all international shipping regulations.
How can I request a quote or sample for Nα-p-Tosyl-L-arginine methyl ester hydrochloride?
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To request a quote or sample, please use the contact form on our website or reach out to our sales team directly. Provide the product name and CAS number (1784-03-8) for prompt service.
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