Nα-Methylhistamine dihydrochloride
Nα-Methylhistamine dihydrochloride (CAS: 16503-22-3) is a white solid chemical compound with the formula C6H11N3 · 2HCl and a molecular weight of 198.09 g/mol. This histamine analogue serves as a valuable tool in biochemical research, particularly in studies involving histamine receptors and cellular signaling pathways. Its well-defined properties make it suitable for investigating physiological responses mediated by histamine.
- IUPAC
- N-Methyl-1H-imidazole-4-ethanamine dihydrochloride,NAMH dihydrochloride
- Synonyms
- N-Methyl-1H-imidazole-4-ethanamine dihydrochlorideNAMH dihydrochloride

Histamine Receptor Research
Nα-Methylhistamine dihydrochloride is utilised as an agonist in research investigating the function and pharmacology of histamine receptors, including H1, H2, H3, and H4 subtypes. It aids in understanding receptor binding and activation mechanisms.
Neuroscience Studies
This compound is applied in neuroscience research to explore the role of histamine in neurotransmission and central nervous system functions. It helps researchers study pathways involved in wakefulness, cognition, and neuroinflammation.
Biochemical Assays
Nα-Methylhistamine dihydrochloride is used in various biochemical assays and in vitro studies to probe biological systems and pathways influenced by histamine. Its use supports the development of new therapeutic strategies.
| Molecular weight | 198.09 |
|---|---|
| Empirical formula | C6H11N3 · 2HCl |
| Assay | (The product is pure based on elemental analysis results, NMR and MS spectra.) |
| Form | solid |
| Colour | white |
| Solubility | H2O: >20 mg/mL |
| Storage temperature | 2-8°C |


Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nα-Methylhistamine dihydrochloride used for?
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Nα-Methylhistamine dihydrochloride is primarily used in scientific research as an agonist for studying histamine receptors and their roles in cellular signaling, neuroscience, and various physiological processes.
What are the CAS number and formula for Nα-Methylhistamine dihydrochloride?
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The CAS number for Nα-Methylhistamine dihydrochloride is 16503-22-3, and its chemical formula is C6H11N3 · 2HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nα-Methylhistamine dihydrochloride based on its purity indicated by elemental analysis, NMR, and MS spectra. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Nα-Methylhistamine dihydrochloride be handled safely?
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Nα-Methylhistamine dihydrochloride is classified as harmful if swallowed, causes skin irritation, serious eye damage, and may cause respiratory irritation. Always handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, in a well-ventilated area.
How is Nα-Methylhistamine dihydrochloride packed, shipped, and exported?
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Nα-Methylhistamine dihydrochloride is typically supplied as a white solid. Tech Serve Solutions adheres to all relevant regulations for packing, shipping, and exporting chemical compounds globally.
How can I request a sample or quote for Nα-Methylhistamine dihydrochloride?
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To request a sample or a quote for Nα-Methylhistamine dihydrochloride, please contact our sales team through the website or by calling us directly.
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