N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine
N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine (CAS: 20734-58-1), with the molecular formula C14H18N2 and a molecular weight of 214.31 g/mol, is a chemical compound utilised in various synthetic organic chemistry applications. It functions as a reagent and an extractant. Available at a purity of 99%, this compound is a valuable building block for chemical synthesis and nitrogen-containing organic molecules.
- IUPAC
- 1,8-Bis(dimethylamino)naphthalene,N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine
- Synonyms
- N′-Tetramethyl-1,8-naphthalenediamine, 20734-58-1, 1,8-Bis(dimethylamino)naphthalene

Protonation Studies
N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine has been employed in the protonation of multiple-charged oligonucleotide anions, contributing to studies in molecular interactions and nucleic acid chemistry.
Catalysis in Organic Reactions
This diamine serves as a reagent in reactions such as the condensation of benzaldehyde with acetic anhydride when catalysed by bismuth nitrate, facilitating specific organic transformations.
Extraction of Organic Acids
The compound's properties allow it to be used as an effective extractant for the separation of organic acids from fermentation broths via liquid-liquid extraction processes.
| Molecular weight | 214.31 |
|---|---|
| Empirical formula | C14H18N2 |
| Assay | 99% |
| Solubility | chloroform: soluble50 mg/mL, clear, faintly yellow to greenish-yellow |
| Application | N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine was used in protonation of multiple-charged oligonucleotide anions1. It was used as reagent during reaction of benzaldehyde with acetic anhydride catalyzed by bismuth nitrate2. It was used as extractant during separation of organic acids from fermentation broths by liquid-liquid extraction3. |
| Melting point | 49-51 °C(lit.) |

Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine used for?
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N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine is used in chemical synthesis, including protonation studies of oligonucleotide anions, as a reagent in organic reactions, and as an extractant for organic acids.
What are the CAS number and molecular formula for N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine?
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The CAS number is 20734-58-1 and the molecular formula is C14H18N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine with an assay of 99%. This is considered a technical/research grade and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine be handled?
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N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine is classified as harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation (H302, H315, H319, H335). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, faceshields, and gloves. Ensure adequate ventilation and avoid breathing dust.
Is N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine a controlled substance?
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The provided data does not indicate that N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine is a controlled substance.
How is N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine packed and shipped?
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N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine is carefully packed for safe transit and is available for export worldwide by Tech Serve Solutions.
How can I request a quote or sample?
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To request a quote or sample of N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine, please contact our sales department through the website or by phone.
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