N,N-Diethylnipecotamide
N,N-Diethylnipecotamide (CAS 3367-95-1; molecular formula C10H20N2O; molar mass 184.28 g/mol) is a piperidine-3-carboxylic acid diethylamide, supplied by Tech Serve Solutions as a research-grade building block at 98 percent assay. A heterocyclic nipecotamide derivative, it serves chiefly as a reactant and intermediate in pharmaceutical and fine-chemical synthesis, including routes to antitubercular and other heterocyclic active compounds. It is offered for research and manufacturing use.
- IUPAC
- N,N-Diethyl-3-piperidinecarboxamide,Piperidine-3-carboxylic acid diethylamide
- Synonyms
- N,N-DiethylnipecotamideN,N-Diethyl-3-piperidinecarboxamidePiperidine-3-carboxylic acid diethylamide3-(N,N-Diethylcarbamoyl)piperidineNipecotic acid diethylamide
Pharmaceutical intermediate
Used as a reactant and building block in the synthesis of pharmaceutical active ingredients and candidate molecules, notably documented in routes towards antituberculosis and antimycobacterial compounds.
Heterocyclic building block
As a substituted piperidine (nipecotamide) scaffold, it provides a versatile C10 heterocyclic core for medicinal-chemistry and chemical-synthesis programmes requiring a piperidine-3-carboxamide motif.
Receptor and enzyme inhibitor synthesis
Reported as a starting material for the preparation of NPC1L1 inhibitors, acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors and alpha-7 nicotinic acetylcholine receptor agonists in published research.
Isocyanide multicomponent reactions
Serves as a precursor to isocyanoamides employed as starting materials in isocyanide-based multicomponent reactions (IMCR) for the rapid assembly of complex molecular libraries.
Research and laboratory reagent
Supplied as a research-grade reagent for exploratory synthesis, analytical reference and process-development work in laboratory settings.
| Molecular weight | 184.28 |
|---|---|
| Empirical formula | C10H20N2O |
| Assay | 98% |
| Boiling point | 111 °C/6.1 mmHg(lit.) |
| Density | 0.989 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.489(lit.) |
| Application | Reactant for synthesis of: Antituberculosis drugs1 Spiroimidazolidinone NPC1L1 inhibitors2 Acyl-CoA:cholesterol acyltransferase inhibitors3 Alpha 7 nicotinic acetylcholine receptor agonist4 Antimycobacterials Isocyanoamides useful as starting materials in IMCR5 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N-Diethylnipecotamide used for?
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N,N-Diethylnipecotamide is used primarily as a reactant and heterocyclic building block in chemical and pharmaceutical synthesis. Documented uses include routes to antituberculosis and antimycobacterial compounds, NPC1L1 inhibitors, ACAT inhibitors, alpha-7 nicotinic acetylcholine receptor agonists, and isocyanoamides for multicomponent reactions.
What is the CAS number and molecular formula of N,N-Diethylnipecotamide?
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Its CAS number is 3367-95-1 and its molecular formula is C10H20N2O, with a molecular weight of 184.28 g/mol. It is also identified by EC number 222-136-1 and MDL number MFCD00005990.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,N-Diethylnipecotamide as a research-grade building block with a typical assay of 98 percent. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch, and full specifications can be confirmed against your requirements on request.
What are the safety and handling precautions for N,N-Diethylnipecotamide?
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It is classified under GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves and eye protection, use adequate ventilation or suitable respiratory protection, avoid breathing dust or mist, and consult the Safety Data Sheet before use. Its German water-hazard class is WGK 3 (highly hazardous to water), so prevent release to the environment.
How is N,N-Diethylnipecotamide packed, shipped and exported?
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It is packed in appropriately sealed laboratory and bulk containers, labelled to GHS requirements and accompanied by the relevant documentation. Tech Serve Solutions arranges compliant domestic and export shipment from India, with pack sizes and Incoterms agreed at the time of order.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged subject to availability and applicable regulatory requirements.
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