N-(2,5-Dibromopyridin-3-yl)pivalamide
N-(2,5-Dibromopyridin-3-yl)pivalamide (CAS 1138444-05-9; C10H12Br2N2O; molar mass 336.02 g/mol) is a halogenated pyridine building block in which a 3-aminopyridine is protected as its pivaloyl amide and carries bromine at the 2- and 5-positions. The two carbon-bromine handles and the directing pivalamide make it a versatile intermediate for regioselective cross-coupling and metal-halogen exchange in pharmaceutical and fine-chemical synthesis. Tech Serve Solutions supplies it as a research-grade intermediate to laboratories and manufacturers worldwide.
- Synonyms
- N-(2,5-Dibromopyridin-3-yl)pivalamide2,2-Dimethyl-N-(2,5-dibromopyridin-3-yl)propanamideN-(2,5-Dibromo-3-pyridinyl)-2,2-dimethylpropanamideCAS 1138444-05-9
Heterocyclic building block
Serves as a multifunctional pyridine scaffold for constructing more elaborate nitrogen heterocycles. The differentiated 2- and 5-bromo positions allow sequential, regioselective elaboration of the ring.
Cross-coupling substrate
The two aryl-bromide bonds are suitable handles for palladium-catalysed couplings such as Suzuki-Miyaura, Negishi and Stille reactions, enabling the installation of aryl, heteroaryl, alkenyl and alkyl groups.
Directed metalation and halogen exchange
The pivalamide acts as a directing and protecting group for the ring nitrogen substituent, while the bromides support lithium- or magnesium-halogen exchange to generate reactive organometallic intermediates.
Pharmaceutical and agrochemical discovery
Used in medicinal-chemistry and discovery programmes where substituted aminopyridine cores are required. It is a research intermediate and is not itself an active pharmaceutical ingredient.
Laboratory research and reference use
Applied in method development, route scouting and structure-activity studies as a defined, single-compound reagent for synthetic chemistry.
| Molecular weight | 336.02 |
|---|---|
| Empirical formula | C10H12Br2N2O |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(2,5-Dibromopyridin-3-yl)pivalamide used for?
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It is used as a halogenated pyridine building block in organic synthesis. Its 2- and 5-bromo substituents and pivalamide group make it a convenient intermediate for cross-coupling, directed metalation and metal-halogen exchange when building substituted aminopyridine structures for pharmaceutical and fine-chemical research.
What is the CAS number and molecular formula of N-(2,5-Dibromopyridin-3-yl)pivalamide?
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The CAS number is 1138444-05-9 and the empirical formula is C10H12Br2N2O (Hill notation), with a molecular weight of 336.02 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research- and technical-grade synthesis intermediate, with batch-specific assay confirmed on the certificate of analysis. We do not represent it as USP, BP or EP pharmacopoeial grade. Please request the current specification for any given lot.
How should N-(2,5-Dibromopyridin-3-yl)pivalamide be handled and stored?
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No specific GHS classification was provided with this listing, so it should be treated as a research chemical and handled by trained personnel using good laboratory practice: wear suitable gloves, eye protection and a lab coat, work with adequate ventilation, and avoid dust, skin and eye contact. Store tightly closed in a cool, dry, well-ventilated place. Always consult the current Safety Data Sheet before use.
How is N-(2,5-Dibromopyridin-3-yl)pivalamide packed, shipped and exported?
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It is packed in sealed, appropriately labelled containers sized from gram research quantities to larger commercial lots, with packaging chosen to protect the material in transit. Tech Serve Solutions exports globally and supplies the required documentation, including a certificate of analysis and Safety Data Sheet, in line with applicable transport and customs requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, quoting CAS 1138444-05-9. We will respond with availability, lead time, specification and a formal quotation, and can arrange a sample where appropriate.
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