N,N-Diethyl-2-(trimethylsilyl)indole-1-carboxamide
N,N-Diethyl-2-(trimethylsilyl)indole-1-carboxamide (CAS 548775-58-2; C16H24N2OSi; molar mass 288.46 g/mol) is a research-grade heterocyclic building block: an indole bearing a trimethylsilyl group at the 2-position and an N,N-diethylcarboxamide on the ring nitrogen. Supplied as a liquid of approximately 90% assay, it serves chemical synthesis and medicinal-chemistry programmes as a protected, regiodefined indole intermediate for the preparation of more elaborate indole-based structures.
- Synonyms
- N,N-Diethyl-2-(trimethylsilyl)indole-1-carboxamideN,N-Diethyl-2-(trimethylsilyl)-1H-indole-1-carboxamide2-(Trimethylsilyl)-N,N-diethyl-1H-indole-1-carboxamideCAS 548775-58-2
Heterocyclic building block
Used as a functionalised indole scaffold in chemical synthesis, providing a defined C2-silyl and N1-carboxamide substitution pattern for onward elaboration.
Medicinal-chemistry intermediate
Employed in discovery and library synthesis where indole cores are required, supporting the construction of more complex drug-like molecules.
Protected indole synthon
The N,N-diethylcarboxamide on the ring nitrogen acts as a protecting and directing group, while the trimethylsilyl group offers a handle for further substitution at the 2-position.
Reference and research material
Suitable as a characterised intermediate for method-development, route-scouting and analytical reference work in laboratory settings.
| Molecular weight | 288.46 |
|---|---|
| Empirical formula | C16H24N2OSi |
| Assay | 90% |
| Density | 1.030 g/mL at 25 °C |
| Refractive index | n20/D 1.555 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N-Diethyl-2-(trimethylsilyl)indole-1-carboxamide used for?
+
It is used primarily as a heterocyclic building block and synthetic intermediate. The molecule combines a 2-trimethylsilyl indole with an N1 carboxamide, making it useful in chemical synthesis and medicinal-chemistry programmes that require a protected, regiodefined indole scaffold for further functionalisation.
What is the CAS number and molecular formula of N,N-Diethyl-2-(trimethylsilyl)indole-1-carboxamide?
+
The CAS number is 548775-58-2. The empirical formula in Hill notation is C16H24N2OSi, corresponding to a molecular weight of 288.46 g/mol.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this compound as a research-grade material with a typical assay of approximately 90%, presented as a liquid (refractive index n20/D 1.555; density 1.030 g/mL at 25 °C). We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided with each batch on request.
What are the safety and handling requirements?
+
It is classified under GHS07 with the signal word Warning and hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves and eye protection, use adequate ventilation or suitable respiratory protection, and avoid breathing dust, mist or vapour (P261, P305+P351+P338). It is assigned WGK 3 (water-hazard class) in Germany. Always consult the Safety Data Sheet before use.
How is N,N-Diethyl-2-(trimethylsilyl)indole-1-carboxamide packed, shipped and exported?
+
It is packed in appropriately sealed, labelled containers sized to the order, from gram research quantities upward, with full documentation including a certificate of analysis and Safety Data Sheet. As a specialist exporter since 1998, Tech Serve Solutions arranges compliant international shipment and export documentation to suit your destination.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with the product name or CAS number 548775-58-2 and your required quantity. We will confirm current availability, lead time and packing, and provide a formal quotation together with the relevant technical and safety documentation.
▶ Related products
4-Amino-2-chloropyridine
C5H5ClN2
Heterocyclic Building Blocks
4-Ethynyl-1-methyl-1H-pyrazole
C6H6N2
Heterocyclic Building Blocks
4-Hydroxyquinoline-3-carboxylic acid ethyl ester
C12H11NO3
Heterocyclic Building Blocks
4-isocyanatopyridine
C6H4N2O
Heterocyclic Building Blocks
5-Chloro-2,8-dimethylquinoline
Heterocyclic Building Blocks
5-Chloro-2-methylene-1,3,3-trimethylindoline
Heterocyclic Building Blocks
5-Chloro-2-thiophenecarbonitrile
Heterocyclic Building Blocks
5-ethynyl-1H-pyrazole
C5H4N2
Heterocyclic Building Blocks▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis