N,N′-Diethylethylenediamine
N,N′-Diethylethylenediamine (CAS: 111-74-0) is a chemical compound with the linear formula CH3CH2NHCH2CH2NHCH2CH3 and a molecular weight of 116.20 g/mol. This diamine serves as a versatile building block in chemical synthesis. Its applications include use as an internal standard in analytical methods and as a reagent for solvation, particularly in organometallic chemistry.
- Synonyms
- 1,2-Bis(ethylamino)ethaneEthane, 1,2-bis(ethylamino)-N,N'-Diethyl-1,2-ethanediamine

Analytical Chemistry Standard
N,N′-Diethylethylenediamine functions as an internal standard in selective liquid chromatographic methods. This is particularly useful for the assay of pharmaceutical compounds like ethambutol in biological samples such as serum.
Solvation Reagent
This compound is employed for the solvation of highly reactive organometallic reagents. For instance, it has been utilised in the solvation of lithium hexamethyldisilazide, facilitating its use in various synthetic transformations.
Organic Synthesis Intermediate
As a diamine, N,N′-Diethylethylenediamine is a valuable building block in organic synthesis. It can be incorporated into more complex molecular structures, including polymers and heterocyclic compounds.
| Molecular weight | 116.20 |
|---|---|
| Linear formula | CH3CH2NHCH2CH2NHCH2CH3 |
| Assay | 95% |
| Boiling point | 152-154 °C(lit.) |
| Density | 0.811 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4326(lit.) |
| Application | N,N′-Diethylethylenediamine has been used as an internal standard in selective liquid chromatographic method developed for the assay of ethambutol in serum samples1. It has also been used for the solvation of lithium hexamethyldisilazide2. |


Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 33 °C / 91.4 °F |
| Transport (UN / ADR) | UN 2685 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 16-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N′-Diethylethylenediamine used for?
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N,N′-Diethylethylenediamine is used as an internal standard in analytical chemistry, particularly for chromatographic assays, and as a solvation reagent in organic synthesis, for example, in the solvation of lithium hexamethyldisilazide.
What is the CAS number and formula for N,N′-Diethylethylenediamine?
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The CAS number is 111-74-0, and its linear formula is CH3CH2NHCH2CH2NHCH2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,N′-Diethylethylenediamine with an assay of 95%. This product is typically supplied as a technical or research grade; TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should N,N′-Diethylethylenediamine be handled safely?
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N,N′-Diethylethylenediamine is a flammable liquid (flash point 33 °C) and causes severe skin burns and eye damage. Handling requires appropriate personal protective equipment including chemical-resistant gloves, eye protection (goggles, face shield), and respiratory protection. Work in a well-ventilated area and avoid sources of ignition.
Is N,N′-Diethylethylenediamine a controlled substance?
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The provided data does not indicate that N,N′-Diethylethylenediamine is a controlled substance. However, users should always verify local regulations.
How is N,N′-Diethylethylenediamine packaged and exported?
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Tech Serve Solutions exports chemicals globally. Packaging is done according to international shipping regulations to ensure safe transport. Please contact us for specific packaging and shipping details for your region.
How can I request a quote or sample?
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To request a quote or a sample of N,N′-Diethylethylenediamine, please use the contact form on our website or email our sales department, providing your details and the required quantity.
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