N-Isopropylacrylamide

CAS 2210-25-5H2C=CHCONHCH(CH3)2Polymer Science

N-Isopropylacrylamide (CAS 2210-25-5) is a chemical monomer with the linear formula H₂C=CHCONHCH(CH₃)₂ and a molecular weight of 113.16 g/mol. It is primarily used in the synthesis of poly(N-isopropylacrylamide) (pNIPA), a thermosensitive polymer known for forming hydrogels. These polymers exhibit a notable phase transition, shrinking significantly at temperatures above 33°C, making them valuable in various material science applications.

IUPAC: NIPAM
Synonyms: NIPAM

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N-Isopropylacrylamide (H2C=CHCONHCH(CH3)2) — chemical structure, CAS 2210-25-5; Materials Science, fine chemical supplied by Tech Serve Solutions

Acrylic MonomersMaterials ScienceMonomersPolymer Science

01 /Applications

Thermosensitive Hydrogel Synthesis

N-Isopropylacrylamide serves as a key monomer for producing poly(N-isopropylacrylamide) (pNIPA) based hydrogels. These hydrogels exhibit a sharp volume phase transition in response to temperature changes.

Smart Polymer Development

The polymerisation of N-Isopropylacrylamide yields polymers that undergo dramatic shrinkage above a critical temperature, approximately 33°C. This characteristic is exploited in the design of 'smart' materials.

Materials Science Research

As a versatile monomer, N-Isopropylacrylamide is instrumental in advanced materials research, particularly in the field of stimuli-responsive polymers and their integration into novel devices and systems.

02 /Properties

Molecular weight	113.16
Linear formula	H2C=CHCONHCH(CH3)2
Assay	97%
Boiling point	89-92 °C/2 mmHg(lit.)
Application	N-Isopropylacrylamide is used to produce poly(N-isopropylacrylamide) (pNIPA, pNIPAAm, pNIPAA or pNIPAm) thermosensitive polymer- or copolymer-based hydrogels. Polymers that contain NIPAM shrink dramatically above 33 °C.
Melting point	60-63 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H319Causes serious eye irritation

Precautionary statements

P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22-36
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2210-25-5

MDL number

MFCD00041913

PubChem substance

24865991

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is N-Isopropylacrylamide used for?

N-Isopropylacrylamide is used to produce poly(N-isopropylacrylamide) (pNIPA) thermosensitive polymer-based hydrogels. These polymers shrink significantly above 33°C, finding applications in smart materials and advanced polymer science.

What are the CAS number and formula for N-Isopropylacrylamide?

The CAS number for N-Isopropylacrylamide is 2210-25-5, and its linear formula is H₂C=CHCONHCH(CH₃)₂.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies N-Isopropylacrylamide with an assay of 97%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.

How should N-Isopropylacrylamide be handled safely?

N-Isopropylacrylamide is classified with Warning signal word, with hazards H302 (Harmful if swallowed) and H319 (Causes serious eye irritation). Recommended personal protective equipment includes a dust mask (N95), eyeshields, faceshields, and gloves. Handle in a well-ventilated area.

How is N-Isopropylacrylamide packed and shipped?

N-Isopropylacrylamide is carefully packaged to ensure safe transit and is available for global export. Specific packaging details can be provided upon request.

How can I request a sample or quote for N-Isopropylacrylamide?

To request a sample or a quote for N-Isopropylacrylamide, please contact our sales team through the website or by phone, providing your specific requirements.