N-Fmoc-piperidine-2-carboxylic acid
N-Fmoc-piperidine-2-carboxylic acid (CAS: 105751-19-7; Formula: C21H21NO4; MW: 351.40) is a protected amino acid derivative supplied by TSS. It serves as a critical building block in peptide chemistry and organic synthesis. This compound is frequently utilised in the development of novel pharmaceutical agents, particularly those targeting proteases, and in the creation of specialised chromatographic materials. Its Fmoc protecting group facilitates controlled peptide chain elongation.
- IUPAC
- 1,2-Piperidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester,Fmoc-DL-pipecolic acid
- Synonyms
- Fmoc-DL-pipecolic acid1,2-Piperidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester
Protease Agonist/Antagonist Synthesis
Used as a reactant in the racemic solid-phase preparation of human protease activated receptor 2 agonists and antagonists, contributing to drug discovery efforts in this area.
Chromatographic Enantiomer Separation
Functions as an analyte in the characterisation of urea-linked cinchona-calexarene hybrid type receptors, essential for chromatographic enantiomer separation of carbamate-protected amino acids.
Combinatorial Chemistry
Employed as a combinatorial reactant for the assembly of alkylglycine library arrays via the SPOT technique on cellulose membranes, aiding in the identification of micromolar ligands for monoclonal antibodies.
| Molecular weight | 351.40 |
|---|---|
| Empirical formula | C21H21NO4 |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Application | Reactant for racemic solid-phase preparation of human protease activated receptor 2 agonists and antagonists1Analyte for urea-linked cinchona-calexarene hybrid type receptors for chromatographic enantiomer separation of carbamate-protected amino acids2Combinatorial reactant for assembly of alkylglycine library arrays by SPOT technique on cellulose membranes for identification of micromolar ligands for monoclonal antibodies3 |
| Melting point | 113-120 °C |
Hazard statements
- H400Very toxic to aquatic life
Precautionary statements
- P273Avoid release to the environment
| Transport (UN / ADR) | UN 3077 9 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | N |
| Risk statements (R) | 50/53 |
| Safety statements (S) | 60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Fmoc-piperidine-2-carboxylic acid used for?
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N-Fmoc-piperidine-2-carboxylic acid is used as a reactant in the solid-phase preparation of protease-activated receptor agonists and antagonists, as an analyte for chromatographic enantiomer separation, and as a reactant for assembling alkylglycine library arrays.
What is the CAS number and formula for N-Fmoc-piperidine-2-carboxylic acid?
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The CAS number is 105751-19-7 and the molecular formula is C21H21NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Fmoc-piperidine-2-carboxylic acid with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated.
How should N-Fmoc-piperidine-2-carboxylic acid be handled and stored?
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N-Fmoc-piperidine-2-carboxylic acid is classified as hazardous to the aquatic environment (H400) and requires careful handling to avoid release. It should be stored at 2-8°C.
How is this chemical packed and exported?
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This chemical is packed and exported according to international shipping regulations for hazardous materials (UN 3077, 9, PGIII).
How can I request a sample or quote?
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Please contact our sales team directly through our website to request a sample or a formal quotation for N-Fmoc-piperidine-2-carboxylic acid.
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