N-Boc-3-(methylamino)piperidine
N-Boc-3-(methylamino)piperidine (CAS: 392331-89-4), with the molecular formula C11H22N2O2 and a molecular weight of 214.30 g/mol, is a key heterocyclic building block. This tert-butyl carboxylate protected piperidine derivative is primarily utilised as a reactant in organic synthesis, notably in the development of complex molecules such as TRPV1 antagonists and aminopiperidines investigated for their potential as iNOS inhibitors.
- IUPAC
- 3-(Methylamino)piperidine-1-carboxylic acid tert-butyl ester
- Synonyms
- 3-(Methylamino)piperidine-1-carboxylic acid tert-butyl ester
Synthesis of TRPV1 Antagonists
N-Boc-3-(methylamino)piperidine serves as a crucial reactant in the synthesis pathways for developing novel TRPV1 antagonists. These compounds are of interest for their potential therapeutic applications in pain management and other related conditions.
Development of iNOS Inhibitors
This piperidine derivative is employed in the synthesis of aminopiperidines, which are being investigated as potential inhibitors of inducible nitric oxide synthase (iNOS). Such research is vital for understanding and potentially treating inflammatory diseases.
General Organic Synthesis
As a versatile building block, N-Boc-3-(methylamino)piperidine finds application in a wide array of complex organic synthesis projects within pharmaceutical research and development, facilitating the construction of nitrogen-containing heterocyclic structures.
| Molecular weight | 214.30 |
|---|---|
| Empirical formula | C11H22N2O2 |
| Assay | 96% |
| Density | 0.983 g/cm3 at 25 °C |
| Refractive index | n20/D 1.467 |
| Storage temperature | 2-8°C |
| Application | Reactant for synthesis of:• TRPV1 antagonists1• Aminopiperidines as iNOS inhibitors2 |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H400Very toxic to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P301IF SWALLOWED
- P305IF IN EYES
| Flash point | >110 °C / >230 °F |
|---|---|
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 25-36/37/38-50 |
| Safety statements (S) | 26-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Boc-3-(methylamino)piperidine used for?
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N-Boc-3-(methylamino)piperidine is primarily used as a reactant in organic synthesis, particularly for the preparation of TRPV1 antagonists and aminopiperidines with potential iNOS inhibitory activity.
What is the CAS number and formula for N-Boc-3-(methylamino)piperidine?
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The CAS number for N-Boc-3-(methylamino)piperidine is 392331-89-4, and its empirical formula (Hill notation) is C11H22N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Boc-3-(methylamino)piperidine with a minimum assay of 96%. This product is intended for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
How should N-Boc-3-(methylamino)piperidine be handled safely?
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N-Boc-3-(methylamino)piperidine is classified as Danger. It is toxic if swallowed (H301), causes skin irritation (H315), causes serious eye irritation (H319), may cause respiratory irritation (H335), and is very toxic to aquatic life (H400). Handle with appropriate personal protective equipment in a well-ventilated area, avoiding release to the environment. Refer to the Safety Data Sheet (SDS) for detailed handling procedures.
Does TSS export N-Boc-3-(methylamino)piperidine globally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including N-Boc-3-(methylamino)piperidine, serving customers worldwide.
How can I request a sample or quote for N-Boc-3-(methylamino)piperidine?
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To request a sample or a quotation for N-Boc-3-(methylamino)piperidine, please visit the Tech Serve Solutions website or contact our sales department directly via the provided contact information.
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