N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide (CAS 189950-66-1) is a synthetic peptide substrate with the molecular formula C26H34N6O13 and a molecular weight of 638.58. This white powder is primarily utilised in biochemical research as a chromogenic substrate for analysing enzyme activity, particularly caspases involved in apoptosis. Its specific sequence allows for targeted enzymatic cleavage, making it a valuable tool for studying cell death pathways.
- IUPAC
- Ac-DEVD-pNA
- Synonyms
- Ac-DEVD-pNA
Enzyme Activity Assays
Used as a specific chromogenic substrate for the quantitative measurement of caspase activity in biochemical and cell-based assays. The release of p-nitroanilide upon enzymatic cleavage allows for spectrophotometric detection.
Apoptosis Research
Essential for investigating the role of caspases in programmed cell death pathways. This substrate helps researchers elucidate caspase activation and function in various biological contexts.
Biochemical Research Tool
A valuable reagent for studying protease kinetics and specificity, particularly for enzymes that recognise the Asp-Glu-Val-Asp sequence.
| Molecular weight | 638.58 |
|---|---|
| Empirical formula | C26H34N6O13 |
| Assay | ≥97% (HPLC) |
| Form | powder |
| Colour | white |
| Storage temperature | −20°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... CASP3(836) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide used for?
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N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide (CAS 189950-66-1) is used as a chromogenic substrate for the enzymatic assay of caspases, particularly those involved in apoptosis, allowing for the quantitative measurement of enzyme activity.
What are the CAS number and formula for N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide?
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The CAS number is 189950-66-1 and the molecular formula is C26H34N6O13.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide with an assay of ≥97% (HPLC). This product is intended for research purposes and is not supplied as USP, BP, EP, or pharmacopoeia grade.
How should N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide be handled and stored?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter. Store at -20°C. The product has a WGK (Germany) rating of 3.
Is this product controlled or scheduled?
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Based on the provided data, there is no indication that N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide is a controlled or scheduled substance.
How can I request a sample or quote?
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To request a sample or quote for N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide, please contact our sales department via the website or by phone.
How is this chemical exported or shipped?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals. Specific shipping and export details for N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide will be provided upon inquiry, adhering to all relevant regulations.
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