Monastrol
Monastrol (CAS 254753-54-3) is a synthetic organic compound with the molecular formula C14H16N2O3S and a molecular weight of 292.35 g/mol. This white to off-white solid is a research chemical primarily utilised in cell biology studies. It functions as a specific inhibitor of the mitotic kinesin Eg5, making it a valuable tool for investigating cell cycle progression and mitosis. Monastrol is supplied by Tech Serve Solutions with a purity of ≥98% (HPLC).
- IUPAC
- 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester
Cell Cycle Research
Monastrol is a selective inhibitor of the Eg5 kinesin motor protein, crucial for bipolar spindle formation during mitosis. Its use allows researchers to study the mechanics and regulation of the cell cycle and understand the consequences of spindle disruption.
Mitosis Investigation
As a specific inhibitor of Eg5, Monastrol is instrumental in dissecting the roles of kinesin motor proteins in chromosome segregation and cell division. It facilitates studies on the dynamics of mitotic spindles and their assembly.
Apoptosis Studies
By inducing mitotic arrest, Monastrol can indirectly trigger apoptotic pathways. This makes it a useful reagent for investigating the relationship between mitotic failure and programmed cell death.
| Molecular weight | 292.35 |
|---|---|
| Empirical formula | C14H16N2O3S |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white to off-white |
| Solubility | DMSO: >5 mg/mL |
| Storage temperature | 2-8°C |
| Melting point | 185-185.9 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Storage Condition | protect from light |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Monastrol used for?
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Monastrol is used in research as a specific inhibitor of the mitotic kinesin Eg5, making it valuable for studying cell cycle progression, mitosis, spindle formation, and apoptosis.
What are the CAS number and formula for Monastrol?
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The CAS number for Monastrol is 254753-54-3, and its empirical formula is C14H16N2O3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Monastrol with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Monastrol be handled and stored?
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Monastrol is a solid chemical. Handle with appropriate personal protective equipment, including eyeshields and gloves. Store at 2-8°C, protected from light, to maintain its stability.
Is Monastrol a controlled substance?
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The provided data does not indicate that Monastrol is a controlled substance.
How is Monastrol packed, shipped, and exported?
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Monastrol is packed as a solid and is available for export globally by Tech Serve Solutions. Specific packaging details can be provided upon request.
How can I request a sample or quote for Monastrol?
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To request a sample or quote for Monastrol, please contact the Tech Serve Solutions sales team through our website or by phone.
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