Methyl crotonate
Methyl crotonate (CAS: 623-43-8), with the linear formula CH₃CH=CHCOOCH₃ and a molecular weight of 100.12 g/mol, is an unsaturated ester. It serves as a valuable building block in organic synthesis. Its applications include use in investigating enzyme-catalysed reactions and as a starting material in the synthesis of complex organic molecules, such as phytotoxins.
Organic Synthesis Intermediate
Methyl crotonate is utilised as a key intermediate in the total synthesis of complex natural products, including phytotoxins like solanapyrones D and E.
Enzymatic Reaction Studies
This compound has been employed in research to study chemoselectivity in enzymatic reactions, specifically involving lipase-catalysed transformations.
Chemical Building Block
As a readily available C5 ester, Methyl crotonate functions as a versatile building block for constructing more complex molecular architectures in academic and industrial research.
| Molecular weight | 100.12 |
|---|---|
| Linear formula | CH3CH=CHCOOCH3 |
| Assay | 98% |
| Boiling point | 118-120 °C(lit.) |
| Density | 0.944 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.423(lit.) |
| Application | Methyl crotonate was used to investigate chemoselectivity in the reaction between methyl crotonate and benzylamine catalyzed by lipase B from Candida antarctica using solvent engineering1. It was used as starting reagent during the total synthesis of phytotoxins solanapyrones D(1) and E(2)2. |
Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -1 °C / 30.2 °F |
| Transport (UN / ADR) | UN 3272 3 / PGII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl crotonate used for?
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Methyl crotonate is primarily used as an intermediate in organic synthesis, for example, in the total synthesis of phytotoxins, and in studies investigating enzyme-catalysed reactions.
What is the CAS number and formula for Methyl crotonate?
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The CAS number for Methyl crotonate is 623-43-8, and its linear formula is CH₃CH=CHCOOCH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl crotonate with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should Methyl crotonate be handled safely?
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Methyl crotonate is a flammable liquid and vapour (H225), causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment including eyeshields, gloves, and ensure adequate ventilation. It has a low flash point of -1 °C.
How is Methyl crotonate packed, shipped, and exported?
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Methyl crotonate is typically packed and shipped according to international regulations for hazardous materials. TSS exports this chemical globally.
How can I request a sample or quote for Methyl crotonate?
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To request a sample or quote, please contact our sales team via the website or direct email, providing your contact details and required quantity.
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