Methyl 4-chloroacetoacetate
Methyl 4-chloroacetoacetate (CAS: 32807-28-6), with the linear formula ClCH₂COCH₂COOCH₃ and a molecular weight of 150.56 g/mol, is a key organic building block. It serves as a versatile intermediate in chemical synthesis, particularly in the creation of heterocyclic compounds. This ester is characterised by its reactive carbonyl and ester groups, alongside a halogen substituent, making it valuable for various synthetic transformations.
Synthesis of Dihydrofurans
Methyl 4-chloroacetoacetate reacts with symmetric allylic diacetates or dicarbonates in the presence of a palladium catalyst. This reaction is a key method for constructing dihydrofuran ring systems, which are important structural motifs in organic chemistry.
Organic Synthesis Intermediate
As a functionalised carbonyl compound and ester, it is widely employed in the synthesis of more complex organic molecules. Its structure allows for diverse reactions, including alkylation, condensation, and cyclisation.
Building Block for Heterocycles
This compound is a valuable precursor for the construction of various heterocyclic compounds. The presence of multiple reactive sites enables its use in diverse cyclisation strategies.
| Molecular weight | 150.56 |
|---|---|
| Linear formula | ClCH2COCH2COOCH3 |
| Assay | 97% |
| Boiling point | 85 °C/4 mmHg(lit.) |
| Density | 1.305 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.456(lit.) |
| Application | Reacts with symmetric allylic diacetates or dicarbonates in the presence of a palladium catalyst to give dihyrofurans.1 |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Flash point | 102 °C / 215.6 °F |
|---|---|
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 4-chloroacetoacetate used for?
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Methyl 4-chloroacetoacetate is primarily used as a building block in organic synthesis, notably for the preparation of dihydrofurans and other heterocyclic compounds.
What are the CAS number and formula for Methyl 4-chloroacetoacetate?
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The CAS number is 32807-28-6, and its linear formula is ClCH₂COCH₂COOCH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl 4-chloroacetoacetate with a minimum assay of 97%. This is a technical/research grade material, and TSS does not represent it as USP, BP, EP, or pharmacopoeia grade.
How should Methyl 4-chloroacetoacetate be handled safely?
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Methyl 4-chloroacetoacetate is classified as Dangerous (GHS06, Signal Word: Danger) with hazard statement H301 (Toxic if swallowed). It also carries European hazard codes T (Toxic) and risk statements R25 (Toxic if swallowed) and R34 (Causes burns). Handle with extreme care in a well-ventilated area, using appropriate personal protective equipment, including gloves, eye protection, and protective clothing. Refer to the Safety Data Sheet for full details.
Is Methyl 4-chloroacetoacetate a controlled substance?
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Based on the provided data, Methyl 4-chloroacetoacetate (CAS 32807-28-6) is not indicated as a controlled or scheduled substance.
How is Methyl 4-chloroacetoacetate shipped and exported?
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As per UN 2810, 6.1/PGIII classification, Methyl 4-chloroacetoacetate is shipped as a toxic solid, liquid or (self-heating) solid, organic, n.o.s. Tech Serve Solutions exports this chemical globally, adhering to all relevant shipping and customs regulations.
How can I request a quote or sample?
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To request a quote or sample of Methyl 4-chloroacetoacetate, please contact the Tech Serve Solutions sales team through our website or by calling our office. Please specify the required quantity and your delivery location.
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